Gene-gene interaction (GGI) plays an important role in the causation of complex diseases, and its importance has now been well recognized through the findings of many successful genome-wide association studies (GWAS). Although many statistical methods have been introduced to address GGI analysis in GWAS, these methods have mainly focused on two-way interactions, rather than on high-order intera...

Les a uteurs presentent l'etude clinique, diagnos­tigue et therapeutique d'un cas diffus de "pied d'ath­tete" (athlete's foot) cause par Trichophyton menta gropbyte. chez un malade frequentant des piscines publiques. Ils signalent ensuite des mesures prophy­lactiques dont la mise en oeuvre se voit necessaire pour la prevention des affectiosn fungiques des es­paces interdigitaux. 

Présentation mise à disposition dans l'attente de la parution du volume aux éditions Cassini

A system for replacing solid-state or relay based industrial control logic with custom firmware, implemented in a standard system is described. A comparison to other approaches, such as OEM implemented high level language based systems and large computer based systems is made. Existing software developments, particularly high level languages for user convenience, are discussed. The approach inc...

Cet article présente un algorithme pour l’ajustement de la présentation d’un document hypermédia dans le but de satisfaire au mieux les exigences de son auteur. Nous modélisons le problème sous la forme d’un problème de tension de coût minimum dans un graphe et proposons un algorithme basé sur la méthode de mise à conformité (out-of-kilter) pour le problème de flot de coût minimum. Dans un prem...

This paper is concerned with the problem of selecting a suitable bandwidth for the presmoothed density estimator from right censored data. An asymptotic expression for the mean integrated squared error (MISE) of this estimator is given, and the smoothing parameters minimizing it are proved to be consistent approximations of the MISE bandwidths. As consequence, a bandwidth selector based on plug...

Human SSB1 (single-stranded binding protein 1 [hSSB1]) was recently identified as a part of the ataxia telangiectasia mutated (ATM) signaling pathway. To investigate hSSB1 function, we performed tandem affinity purifications of hSSB1 mutants mimicking the unphosphorylated and ATM-phosphorylated states. Both hSSB1 mutants copurified a subset of Integrator complex subunits and the uncharacterized...

english): From a wavelet analysis, one derives a nonparametrical estimator for the spectral density of a Gaussian process with stationary increments. First, the idealistic case of a continuous time path of the process is considered. A punctual Central Limit Theorem (CLT) and an estimation of the Mean Integrate Square Error (MISE) are established. Next, to fit the applications, one considers the...