Human JC polyomavirus (JCV) is the etiologic agent of the neurodegenerative disease progressive mulifocal leukoencephalopathy. By using JCV as a model, we investigated the role of the viral early protein tumor antigen (TAg) in the binding of two cellular proteins, Pura alpha and YB-1, to JCV regulatory sequences. Results from band-shift assays with purified YB-1, Pur alpha, and TAg indicated th...

In this article, we propose a Partition ofUnity Refinement (PUR)method to improve the local approximations of elliptic boundary value problems in regions of interest. The PUR method only needs to refine the local meshes and hanging nodes generate no difficulty. The mesh qualities such as uniformity or quasi-uniformity are kept. The advantages of the PUR include its effectiveness and relatively ...

Objective To investigate the effects of puerarin (Pur) on myocardial perfusion and ventricular wall motion in patients with acute coronary syndrome (ACS). Methods Thirty-seven patients with ACS were randomly divided into two groups: conventional treatment group (n=17, 11 males, range of age: 32-80 years, average age: 60.9±4.9 years) and Pur treatment group (n=20,12 males, range of age: 40-76 ye...

Amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD) share phenotypic and pathologic overlap. Recently, an expansion of GGGGCC repeats in the first intron of C9orf72 was found to be a common cause of both illnesses; however, the molecular pathogenesis of this expanded repeat is unknown. Here we developed both Drosophila and mammalian models of this expanded hexanucleotide repea...

OBJECTIVE To determine if a dual-purpose bone graft can regenerate bone and reduce infection in highly contaminated bone critical size defects in rats. METHODS Biodegradable polyurethane (PUR) scaffolds were loaded with recombinant human bone morphogenetic protein-2 (BMP-2) and vancomycin (Vanc). The release kinetics of the BMP-2 were tuned to take advantage of its mechanism of action (ie, an...

Objective: Congenital hydronephrosis is a common prenatally diagnosed anomaly associated with an incidence of approximately 0.5-1% in newborns. The purpose of this study was to clarify the value of 99 m diethylenetriamine pentaacetic acid (99mTc-DTPA) in the assessment of renal function impairment of pediatric hydronephrosis. Methods: A total of 48 children with unilateral ureteropelvic junctio...

Infection is a common complication in open fractures that compromises the healing of bone and can result in loss of limb or life. Currently, the clinical standard of care for treating contaminated open fractures comprises a staged approach, wherein the wound is first treated with non-biodegradable antibiotic-laden poly(methyl methacrylate) (PMMA) beads to control the infection followed by bone ...

BACKGROUND Intrauterine Insemination (IUI) remains the first thought of infertility treatment. OBJECTIVE To compare the stimulation effects and Pregnancy rate (PR) outcomes of two ovulation induction (OI) medications, human-derived menopausal gonadotrophins (hMGH), Merional (MER), and recombinant follicular stimulating hormone (rFSH), Puregon (PUR), in a cohort of Saudi infertile patients, fo...

We used California's Pesticide Use Report (PUR) and land-use survey data to conduct a simulation study evaluating the potential consequences of misclassifying residential exposure from proximity to agricultural pesticide application in health effect studies. We developed a geographic model linking the PUR with crop location data from land-use surveys to assess the impact of exposure misclassifi...

Lipopurothionins are complexes of basic polypeptides and polar lipids found in petroleum ether extracts of wheat endosperm. Location of the structural genes for the protein moiety and of genes probably controlling the lipid moiety has been achieved by analysis of compensated nulli-tetrasomic and ditelosomic lines of Triticum aestivum L. cv. Chinese Spring, as well as of other genetic stocks. Th...