Scorpion venom is a rich source of toxins which have great potential to develop new therapeutic agents. Scorpion chloride channel toxins (ClTxs), such as Chlorotoxin selectively inhibit human Matrix Methaloproteinase-2 (hMMP-2). The inhibitors of hMMP-2 have potential use in cancer therapy. Three new ClTxs, meuCl14, meuCl15 and meuCl16, derived from the venom transcriptome of Iranian scorpion, ...

Scorpion venom is a rich source of toxins which have great potential to develop new therapeutic agents. Scorpion chloride channel toxins (ClTxs), such as Chlorotoxin selectively inhibit human Matrix Methaloproteinase-2 (hMMP-2). The inhibitors of hMMP-2 have potential use in cancer therapy. Three new ClTxs, meuCl14, meuCl15 and meuCl16, derived from the venom transcriptome of Iranian scorpion, ...

A fully relativistic modified gravitational theory including a fifth force skew symmetric field is fitted to the Pioneer 10/11 anomalous acceleration. The theory allows for a variation with distance scales of the gravitational constant G, the fifth force skew symmetric field coupling strength ω and the mass of the skew symmetric field μ = 1/λ. A fit to the available anomalous acceleration data ...

an ideal orthodontic force system should exert continuous light force. thus, many efforts have been made to improve the memory characteristics of elastomeric chains. the aim of this study was to compare elastomeric chains (ecs) claimed by their manufacturers to offer high memory with traditional ones according to their force-extension diagrams.in this in-vitro study, ecs were divided into six g...

Mitotic spindles maintain a roughly constant length in metaphase, so the forces between the spindle poles are balanced. A new study involving screening molecules believed to mediate this force balance has found that spindle length is relatively insensitive to perturbations of molecular motor force-generating activities, but more sensitive to perturbation of microtubule assembly regulators and c...

Molecular dynamics simulations are obtained and analyzed to study pairing of 1-hexyl-3-methylimidazolium and tetrafluoroborate ions in n-pentanol, in particular by evaluating the potential-of-mean-force between counter ions. The present molecular model and simulation accurately predicts the dissociation constant K(d) in comparison to experiment, and thus the behavior and magnitudes for the ion-...

Motivated by the simple models of molecular motor obeying a linear force-velocity relation, we have studied stochastic dynamics Brownian particle in presence velocity dependent force, $$f_s(1-\frac{v}{v_0})$$ where $$f_{s}$$ is constant. The position and auto correlation functions different situations are calculated exactly. We observed that function shows an exponentially decaying behaviour wi...