Young Mi Kwon, Jaewon Lee, Hyung Suk Baik, Byung Pal Yu and Hae Young Chung* College of Pharmacy, Pusan National University, Busan 609-735, Korea MRC for Ischemic Tissue Regeneration, College of Medicine, Pusan National University, Busan 602-739, Korea 3 Genetic Engineering Research Institute, Pusan National University, Busan, 609-735, Korea Department of Physiology, The University of Texas Hea...

Sera from virtually all individuals infected with human immunodeficiency virus contain antibodies against the viral envelope glycoproteins. By using a series of synthetic peptide antigens, we identified an immunodominant domain at amino acid position 598-609 of gp41. The minimal essential epitope is a 7-amino-acid sequence (amino acids 603-609) containing two cysteine residues. Both cysteine re...

Three accurate X-ray diffraction experiments (Mo Kalpha, T = 190, 240 and 298 K) were carried out to track the temperature dependence of the electron density in the cubic perovskite potassium manganese trifluoride, KMnF3, from room temperature to just above that of the phase transition to the tetragonal structure (186 K), and to correlate the parameters of the critical points with the phase-tra...

During the synthesis of the new antimalarial drug candidate NITD609, a high degree of diastereoselectivity was observed in the Pictet-Spengler reaction. By isolating both the 4E and 4Z imine intermediates, a systematic mechanistic study of the reaction under both kinetic and thermodynamic conditions was conducted. This study provides insight into the source of the diastereoselectivity for this ...

effects of the brown tide alga, Aureococcus anophagefferens Mary Downes Gastrich1¤ and Catherine E. Wazniak2 1New Jersey Department of Environmental Protection, Division of Science, Research and Technology, Trenton, New Jersey, USA 2Maryland Department of Natural Resources, Annapolis, Maryland, USA *Corresponding author: New Jersey Department of Environmental Protection, Division of Science, Re...

Chang-Do Huh and Keum-Shik Hong a Department of Mechanical and Intelligent Systems Engineering, Pusan National University, 30 Jangjeon-Dong, Kumjeong-Ku, Pusan, 609-735, Korea. Tel: +82-51-510-1481, Fax: +82-51-514-0685, Email: [email protected] b School of Mechanical Engineering, Pusan National University, 30 Jangjeon-Dong Kumjeong-Ku, Pusan 609-735, Korea. Tel: +82-51-510-2454, Fax: +82-51-51...

The Ca(2+)/calmodulin (CaM) competitive inhibitor KN-93 has previously been used to evaluate 5'-AMP-activated protein kinase (AMPK)-independent Ca(2+)-signaling to contraction-stimulated glucose uptake in muscle during intense electrical stimulation ex vivo. With the use of low-intensity tetanic contraction of mouse soleus and extensor digitorum longus (EDL) muscles ex vivo, this study demonstr...

Mixed-valent Mn/O dinuclear and polynuclear molecular compounds containing Mn are almost without exception trapped valence. Large differences between the strengths of the exchange interactions within MnMn, MnMn and MnMn pairs lead to situations where MnMn interactions, the strongest of the three mentioned and antiferromagnetic in nature, dominate the intramolecular spin alignments in trinuclear...