matrix metalloproteinases (mmps) play an important role in gastric cancer (gc). accumulated evidence suggests that functional mmp-1 and mmp-7 gene polymorphisms are associated with several tumors. the aim of this study was to investigate two single nucleotide polymorphisms, mmp-1 -1607 1g/2g and mmp-7 -181 a/g, and their potential relationship with gc. we examined 246 gc  patients and 252 age-a...

background: current treatments for joint diseases are moderately successful, but unfortunately are associated with significant side effects. this study was undertaken to investigate the combination effects of il-4 and prednisolone on tissue characteristics and production of matrix metalloproteinase-1(mmp-1) in il-lα-treated bovine nasal cartilage (bnc) explants. methods: bnc explants were cultu...

Background: Whilst ~40% of ACPA-negative RA-patients achieve sustained DMARD-free remission (SDFR; the absence synovitis after DMARD-cessation), biological pathways involved in SDFR-development are incompletely understood. Previously, high baseline levels MMP-3, SAA and CRP were found achieving SDFR. Differences biomarker might reflect distinct underlying leading towards disease resolution this...

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Hereditary predisposition is one of the aetiopathogenetic factors in development gastric ulcer and duodenal ulcer. The analysis literature materials allows us to identify a number candidate genes that play role formation peptic ulcer: PSCA, ABO, IL1β, IL1RN, TNFα, HSP70-1, GSR, TLR4, TLR2, TLR9, MMP-1, MMP-3, MMP- 9, TIMP-3, PGC, MIF, MPO, COX-1. Considering most studies were carried out abroad...

background: previous studies have shown that some cytokines have protective effects on cartilage in joint diseases. in the current study, effects of il-4 against morphological changes and tissue degradation induced by il-1α on bovine nasal cartilage (bnc) explants were investigated. methods: fresh bnc samples were prepared from a slaughterhouse under sterile conditions. bnc explants culture was...

introduction: exercise training increases skeletal muscle capillary density, but the molecular mechanisms of this process are not yet clear. the aim of the present study was to investigate the effect of acute long- term submaximal exercise on serum vascular endothelial growth factor (vegf) as the main angiogenic factor, and matrix metalloproteinases 2 and 9 ( mmp-2 and mmp-9), as the degrading ...