Providing high quality of Web services is now very important for most of the services. In this article, we present the MLF (Most Loaded First) system, adaptive and intelligent cluster-based Web system. The MLF system provides Quality of Web Service (QoWS) on a fixed level, guaranteeing the page response time within established boundaries, even if Web servers are heavy loaded. We present experim...

MLF is a language that extends ML and System F and combines the benefits of both. We propose a dag representation of MLF types that superposes a term-dag, encoding the underlying term structure with sharing, and a tree encoding the binding structure. Compared to the original definition, this representation is more canonical, as it factors out most of the notational details; it is also closely r...

Oncostatin-M (OSM) is an IL-6/gp130 family member that can stimulate the eosinophil-selective CC chemokine eotaxin-1 in vitro and eosinophil accumulation in mouse lung in vivo. The adhesion molecule VCAM-1 and eotaxin have been implicated in extravasation and accumulation of eosinophils into tissue in animal models of asthma. In this study, we investigated the role of OSM in regulation of VCAM-...

We propose a type system MLF that generalizes ML with first-class polymorphism as in System F. Expressions may contain second-order type annotations. Every typable expression admits a principal type, which however depends on type annotations. Principal types capture all other types that can be obtained by implicit type instantiation and they can be inferred. All expressions of ML are well-typed...

Malolactic fermentation (MLF) is carried out by Oenococcus oeni under very harsh conditions. This paper shows that stress compounds in wine such as SO(2), fatty acids and copper have an inhibitory effect on cell growth and MLF duration, and relates this effect to an inhibition of ATPase activity. Of the stress compounds, SO(2) and dodecanoic acid had the strongest effect, decreasing the ATPase ...

During malolactic fermentation (MLF) in grape must and wine, heterofermentative lactic acid bacteria may degrade arginine, leading to the formation of ammonia and citrulline, among other substances. This is of concern because ammonia increases the pH and thus the risk of growth by spoilage bacteria, and citrulline is a precursor to the formation of carcinogenic ethyl carbamate (EC). Arginine me...

Modern embedded systems are being modeled as Heterogeneous Reconfigurable Computing Systems (HRCS) where Reconfigurable Hardware i.e. Field Programmable Gate Array (FPGA) and soft core processors acts as computing elements. So, an efficient task distribution methodology is essential for obtaining high performance in modern embedded systems. In this paper, we present a novel methodology for task...

The nontoxic mutant lethal factor (mLF; which has the E687C substitution) and functional protective antigen (PA63) of Bacillus anthracis were evaluated for their use as mucosal vaccines against anthrax in A/J mice. Intranasal vaccination of three doses of 30 microg of mLF or 60 microg of PA63 elicited significant serum and mucosal antibody responses, with anthrax lethal toxin-neutralizing titer...

There are errors in the Author Contributions. Christoph Buettner should be listed as one of the persons who conceived and designed the experiments, analyzed the data, contributed reagents/materials/analysis tools and contributed to the writing of the manuscript. The correct contributions are: Conceived and designed the experiments: MLM and CB. Performed the experiments: MLM EK CL MLF. Analyzed ...