case presentation an elderly woman in a manic phase of bipolar disorder without a previous history of psychiatric disorders was concomitant with problematic sexual over stimulation in the context of hyper sexuality. she had traumatized her genitals and underwent surgery for their repair. following her admission and psychopharmacologic therapy, she recovered. introduction late onset bipolar diso...

BACKGROUND In women with mixed urinary incontinence, pelvic floor muscle training and solifenacin is the recommended conservative treatment, while electroacupuncture is a safe, economical and effective option. METHODS/DESIGN In this prospective, multi-center, randomized controlled trial, five hundred women with mixed urinary incontinence, from 10 centers will be randomized to receive either e...

BACKGROUND No study has investigated when preventive treatment with lithium should be initiated in bipolar disorder. AIMS To compare response rates among patients with bipolar disorder starting treatment with lithium early v. late. METHOD Nationwide registers were used to identify all patients with a diagnosis of bipolar disorder in psychiatric hospital settings who were prescribed lithium ...

OBJECTIVES As only a few studies so far systematically reported on bipolar patients subtyped according to first-episode polarity, we took the opportunity of having at disposal a large sample of bipolar I patients to specify the characteristics of patients included in these subtypes, with a special focus on temperament and triggering events. METHODS A total of 1089 consecutive DSM-IV bipolar I...

BACKGROUND Valproate is one of the most used mood stabilisers for bipolar disorder, although the evidence for the effectiveness of valproate is sparse. AIMS To compare the effect of valproate v. lithium for treatment of bipolar disorder in clinical practice. METHOD An observational cohort study with linkage of nationwide registers of all people with a diagnosis of bipolar disorder in psychi...

OBJECTIVES To investigate whether routinely collected data from hospital episode statistics could be used to identify the gynaecologist Rodney Ledward, who was suspended in 1966 and was the subject of the Ritchie inquiry into quality and practice within the NHS. DESIGN A mixed scanning approach was used to identify seven variables from hospital episode statistics that were likely to be associ...

Little is known concerning the prognostic significance of manic/mixed episodes in adolescents. In particular, whether the use of psychodynamic-oriented projective psychological testing predicts evolution to schizophrenia at follow-up has not been established. Eighty subjects, aged 12-20years old, consecutively hospitalized for a manic or mixed episode between 1994 and 2003 were recruited. All p...

The complex relationship between the use of antidepressants and suicidal behaviour is one of the hottest topics of our contemporary psychiatry. Based on the literature, this paper summarizes the author's view on antidepressant-resistant depression and antidepressant-associated suicidal behaviour. Antidepressant-resistance, antidepressant-induced worsening of depression, antidepressant-associate...