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mitochondria are membrane-enclosed organelle found in most eukaryotic cells, which known as power house in cells. this organelle transforms energy into forms that are usable by the cell. the most common psychiatric disorders such as depression and anxiety can be linked to mitochondrial disorders. furthermore, mutations of mitochondrial or nuclear dna (mtdna and ndna, respectively) have been lin...

mitochondrial myopathy, lactic acidosis, and sideroblastic anemia (mlasa) syndrome is a rare autosomal recessive disorder of oxidative phosphorylation and iron metabolism. the association between myopathy and sideroblastic anemia was initially reported in 1974. here we report an 8.5 year old boy with normal cognitive function, suffering from chronic progressive weakness in his lower extremities...

objective mitochondrial dna (mtdna) is considered a candidate modifier factor for neuro-degenerative disorders. the most common type of ataxia is friedreich's ataxia (fa). the aim of this study was to investigate different parts of mtdna in 20 iranian fa patients and 80 age-matched controls by polymerase chain reaction (pcr) and automated dna sequencing methods to find any probable point mutati...

background: mitochondrial transfer rnas (trna) genes are essential components of protein biosynthesis. these genes are hotspots for mutations. these mutations are associated with a wide spectrum of human disease. many genetic factors are known in assessment of repeated pregnancy loss (rpl). objective: the aim of this study was analysis of trna thr and trna pro in women with rpl. materials and m...

hypoparathyroidism as the first manifestation of kearns-sayre syndrome: a case report   how to cite this article: ashrafzadeh f, ghaemi n, akhondian j, beiraghi toosi m, elmi s. hypoparathyroidism as the first manifestation of kearns-sayre syndrome: a case report. iran j child neurol. 2013 autumn;7(4):53-57.     objective kearns-sayre syndrome is a mitochondrial myopathy, which was first descri...

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in order to perform breeding programs and improve production of native chickens, preserving genetic diversity in different areas of iran is important due to the reduced available population. genome sequencing is considered the most functional approach to determine the phylogeny relation between close populations. the aim of the present study was the evaluation of the phylogeny and genetic nucle...