alzheimer’s disease (ad) is a progressive neurodegenerative disorder that affects regions of the brain that control cognition, memory, language, speech and awareness to one’s physical surroundings. the pathological initiation and progression of ad is highly complex and its prevalence is on the rise. in his study, alzheimer's disease was induced with single injection of amyloid-β (aβ) pepti...

Cancer Therapy In article number 2007778, Lin Li, Shao Q. Yao, Wei Huang, and co-workers review the different mitochondria-targeting functional units (Mito-Bomb), various cancer treatment strategies that target mitochondria. picture, commander (scientist or doctor) controls “Mito-Bomb”, which indicates accurate destruction of mitochondria in tumor cells to achieve precise tumors.

Anti-oxidant effects of propofol (2, 6-diisopropylphenol) were evaluated agains carbon tetrachloridet CCl4 -induced oxidative stress in rat liver. 30 male rats were equally divided in to 6 groups (5 rats each). Group I (control), while Group II was given CCl4 (3 mL /Kg/day, IP). Animals of Groups III received only propofol (10 mg/Kg/day, IP). Group IV was given propofol+ CCl4. Group V was admin...

Anti-oxidant effects of propofol (2, 6-diisopropylphenol) were evaluated agains carbon tetrachloridet CCl4 -induced oxidative stress in rat liver. 30 male rats were equally divided in to 6 groups (5 rats each). Group I (control), while Group II was given CCl4 (3 mL /Kg/day, IP). Animals of Groups III received only propofol (10 mg/Kg/day, IP). Group IV was given propofol+ CCl4. Group V was admin...

background: the objective of this study was to investigate the effect of vitrification and in vitro maturation on the mitochondrial distribution and atp content of oocytes. methods: the oocytes at germinal vesicle (gv) and metaphase ii (mii) stages were recovered from 6-8 week old nmri strain female mice. the oocytes were divided into vitrified and non-vitrified groups. vitrification was done b...

conclusions the results suggest the important role of the antioxidant system potentiation in the prevention of myocardial damage. results cell degenerative changes, pyknotic nuclei, contraction bands, edema, and loosening of collagen in between muscle fibers were observed during ischemia-reperfusion. myocardial architecture and cellular morphology were recovered in co-administration groups, esp...

•The presence of MAMs and matrix granules in AML cell lines is evidence that there are active communication processes between endoplasmic reticulum mitochondria AML. •HL60 carrying high levels favor conserved has a higher sensitivity to drugs targeting (rotenone/antimycin). •Conversely, K562, the ASXL1 mutation, exhibits decrease numbers granules, MAM, MDV precursors associated with chemoresist...

results the results reveal that pq can decrease mitochondrial viability, deplete gsh content, increase mitochondrial ros formation, and enhance lpo and mitochondrial membrane damage. the pretreatment of mitochondria with ng has the ability to reduce the toxic effects of pq in isolated mitochondria. background paraquat (pq) is a dipyridyl herbicide that sustains damage due to redox cycling. an i...