نتایج جستجو برای: mild cerebral hypoperfusion

تعداد نتایج: 296125  

2017
Glenn M. Eastwood Alistair Nichol Matt P. Wise Mypinder S. Sekhon Philip N. Ainslie Donald E. Griesdale

Cardiac arrest (CA) causes ischaemic brain injury and persistent cerebral hypoperfusion and cerebral hypoxia during the early post-resuscitation period. PaCO2 is the major physiological regulator of cerebral blood flow, is a modifiable component of care and mild hypercapnia may lead to improved neurological outcomes for resuscitated CA survivors. In order to evaluate the potential therapeutic r...

2017
Chang Gu Kang Min Ho Chun Jung-A Kang Kyung Hee Do Su Jin Choi

OBJECTIVE To demonstrate the prevalence of cerebral hypoperfusion without focal cerebral lesions in patients with Moyamoya disease (MMD), and the relationship between areas of hypoperfusion and cognitive impairment. METHODS Twenty-six MMD patients were included. Patients were categorized according to the presence/absence of hypoperfusion in the frontal, parietal, temporal, and occipital lobes...

Journal: :Journal of nuclear medicine : official publication, Society of Nuclear Medicine 2002
Yoshifumi Sugawara Takanori Kikuchi Toshihiro Ueda Mamoru Nishizaki Shigeru Nakata Teruhito Mochizuki Junpei Ikezoe

UNLABELLED The purpose of this study was to evaluate the usefulness of SPECT during temporary carotid balloon occlusion testing and to evaluate the changes in regional cerebral blood flow (CBF) and regional cerebral perfusion reserve (CPR) after permanent carotid occlusion. METHODS Temporary balloon occlusion testing was performed on 40 patients (24 head and neck tumors, 16 aneurysms). During...

Journal: :Cerebral cortex 2014
Ozioma C Okonkwo Guofan Xu Jennifer M Oh N Maritza Dowling Cynthia M Carlsson Catherine L Gallagher Alex C Birdsill Matthew Palotti Whitney Wharton Bruce P Hermann Asenath LaRue Barbara B Bendlin Howard A Rowley Sanjay Asthana Mark A Sager Sterling C Johnson

Cerebral blood flow (CBF) provides an indication of the metabolic status of the cortex and may have utility in elucidating preclinical brain changes in persons at risk for Alzheimer's disease (AD) and related diseases. In this study, we investigated CBF in 327 well-characterized adults including patients with AD (n = 28), patients with amnestic mild cognitive impairment (aMCI, n = 23), older co...

Knokwan Tilokskulchai Wachirayah Thong-asa

Objective(s):The present study investigated the effect of long-term mild cerebral hypoperfusion induced by permanent unilateral (right) common carotid artery occlusion (UCO) on the dorsal hippocampal neurons in rats. Materials and Methods:Sixty four male Sprague-Dawley rats aged 4 months were divided into two groups of sham and UCO. These two groups were further divided into 4 sets of histopath...

Journal: :Journal of Alzheimer's disease : JAD 2013
Je-Seong Won Jinsu Kim Balasubramaniam Annamalai Anandakumar Shunmugavel Inderjit Singh Avtar K Singh

Chronic cerebral hypoperfusion (CCH), featuring in most of the Alzheimer's disease spectrum, plays a detrimental role in brain amyloid-β (Aβ) homeostasis, cerebrovascular morbidity, and cognitive decline; therefore, early management of cerebrovascular pathology is considered to be important for intervention in the impending cognitive decline. S-nitrosoglutathione (GSNO) is an endogenous nitric ...

Journal: :Stroke 1994
L H Sekhon M K Morgan I Spence N C Weber

BACKGROUND AND PURPOSE Studies in acute cerebral ischemia have shown that reductions in cerebral blood flow of up to 50% do not lead to infarction or alterations in neuronal electric activity. Little is known about the effects of chronic reductions in cerebral blood flow. The purpose of this study was to evaluate neuronal electrophysiological function in brain that had been subjected to a chron...

Journal: :Frontiers in Aging Neuroscience 2016

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