Previous studies have provided evidence of structural and task-related functional changes in the brains of patients with migraine without aura. Resting-state brain activity in patients with migraine provides clues to the pathophysiology of the disease. However, few studies have focused on the resting-state abnormalities in patients with migraine without aura. In the current study, we employed a...

OBJECTIVE To examine the association between a lifetime history of migraines and other headaches with and without aura and Rose angina and coronary heart disease (CHD). METHODS Participants were 12,409 African American and white men and women from the Atherosclerosis Risk in Communities Study, categorized by their lifetime history of headaches lasting > or =4 hours (migraine with aura, migrai...

The hypothesis of cytokines as possible pain mediators in neurovascular inflammation offers a potential mechanism for the generation of migraine pain, but few studies examined cytokine levels in migraine patients. The aim of this study was to determine the levels of TNF-α, IL-4, IL-5, IL-6, IL-10, and IFN-γ in serum of patients with migraine during attacks and attack-free periods. We evaluated ...

BACKGROUND Diffusion tensor imaging (DTI) study revealed reduced fractional anisotropy (FA) values in the corpus callosum (CC) in migraine patients without aura. Abnormalities in white matter integrity, particularly in the CC, may affect inter-hemispheric resting state functional connectivity (RSFC). Unfortunately, relatively little is known about the alterations in functional interactions betw...

The study presented here is the first detailed nosographic analysis of migraine aura, diagnosed using the criteria of the International Headache Society, in a sufficiently large sample for statistical analysis. Of 4,000 people, 163 had migraine with aura. Sixty-two had attacks of migraine aura with headache as well as migraine aura without headache, and seven had exclusively migraine aura witho...

background: migraine with aura (ma) has been identified as a risk factor for cardiovascular disease. previous observation has also found higher prevalence of cardiovascular risk factors in migraineurs without aura (mo), but the results have been conflicting. the present study was conducted to assess the association between cardiovascular risk factors and migraine without aura among iranians. me...

Migraine with aura is prevalent in high-altitude populations suggesting an association between migraine aura and hypoxia. We investigated whether experimental hypoxia triggers migraine and aura attacks in patients suffering from migraine with aura. We also investigated the metabolic and vascular response to hypoxia. In a randomized double-blind crossover study design, 15 migraine with aura pati...

OBJECTIVE To evaluate the association between migraine and cognitive decline among women. DESIGN Prospective cohort study. SETTING Women's Health Study, United States. PARTICIPANTS 6349 women aged 65 or older enrolled in the Women's Health Study who provided information about migraine status at baseline and participated in cognitive testing during follow-up. Participants were classified i...

Objective To evaluate the association between migraine and cognitive decline among women. Design Prospective cohort study. SettingWomen’s Health Study, United States. Participants 6349 women aged 65 or older enrolled in the Women’s Health Study who provided information about migraine status at baseline and participated in cognitive testing during follow-up. Participants were classified into fou...