The synthesis of halogenated and trifluoromethylated α-boryl ketones via a one-pot oxidative difunctionalization of alkenyl MIDA boronates is reported. These novel densely functionalized organoborons bearing synthetically and functionally valuable carbonyl, halogen/CF3 and boronate moieties within the same molecule are synthetically challenging for the chemist, but have great synthetic potentia...

More than five decades ago Bruce Merrifield introduced the idea of automation to organic chemistry through the use of solid supports as an enabling technology that facilitates synthesis as well as work-up. The age of combinatorial chemistry popularized solid-phase-assisted synthesis, but also paved the way for new enabling technologies and technical devices such as liquid-handling systems, radi...

Puchowicz, Michelle A., Ilya R. Bederman, Blandine Comte, Dawei Yang, France David, Eric Stone, Kareem Jabbour, David H. Wasserman, and Henri Brunengraber. Zonation of acetate labeling across the liver: implications for studies of lipogenesis by MIDA. Am. J. Physiol. 277 (Endocrinol. Metab. 40): E1022–E1027, 1999.—Measurement of fractional lipogenesis by mass isotopomer distribution analysis (M...

A multicomponent indicator displacement assay (MIDA) based on an organometallic receptor and three dyes can be used for the identification and quantification of nucleotides in aqueous solution at neutral pH.

MIDA boronates (N-methylimidodiacetic boronic acid esters) serve as an increasingly general platform for small-molecule construction based on building blocks, largely because of the dramatic and general rate differences with which they are hydrolysed under various basic conditions. Yet the mechanistic underpinnings of these rate differences have remained unclear, which has hindered efforts to a...

The phytochrome (phy)-interacting basic helix-loop-helix transcription factors (PIFs) constitutively sustain the etiolated state of dark-germinated seedlings by actively repressing deetiolation in darkness. This action is rapidly reversed upon light exposure by phy-induced proteolytic degradation of the PIFs. Here, we combined a microarray-based approach with a functional profiling strategy and...

The structure of the title compound, [(NH4)0.8K0.2][Cr(C5H7NO4)2] (C5H7NO4 is methyl-iminodi-acetate; mida), has been determined from synchrotron data. The Cr(III) atom is located on a centre of symmetry and is coordinated by two N atoms and four O atoms of two facially arranged tridentate mida ligands, displaying a slightly distorted octa-hedral coordination environment. The Cr-N and mean Cr-O...