Mobility impairment in older persons is associated with brain white matter hyperintensities (WMH), a common finding in magnetic resonance images and one established imaging biomarker of small vessel disease. The contribution of possible microstructural abnormalities within normal-appearing white matter (NAWM) to mobility, however, remains unclear. We used diffusion tensor imaging (DTI) measures...

BACKGROUND Traumatic spinal cord injury (SCI) leads to disruption of axonal architecture and macroscopic tissue loss with impaired information flow between the brain and spinal cord-the presumed basis of ensuing clinical impairment. OBJECTIVE The authors used a clinically viable, multimodal MRI protocol to quantify the axonal integrity of the cranial corticospinal tract (CST) and to establish...

Aging is associated with microstructural white matter (WM) changes. WM microstructural characteristics, measured with diffusion tensor imaging (DTI), are different in normal appearing white matter (NAWM) and WM hyperintensities (WMH). It is largely unknown how the microstructural properties of WMH are associated with cognition and if there are regional effects for specific cognitive domains. We...

Abstract Background Autosomal dominant Alzheimer's Disease (ADAD) is an important area of study to understand the pathogenesis AD. Previous studies suggested that mutations in genes coding for amyloid precursor protein cause early deposition amyloid‐β peptide (Aβ), resulting amyloid‐induced inflammatory response and cortical microstructural changes during cognitively asymptomatic phase, several...

White structure flaking (WSF) has been found to be one of the failure modes in bearing steels under rolling contacts through the formation of cracks associated with a microstructural change called white etching area (WEA). In the present research, the effects of the high-pressure torsion (HPT) process on the microstructure and mechanical properties of an AISI 52100 alloy are studied. An anneale...