multiple myeloma (mm), is the second most common blood cancer after non-hodgkin’s lymphoma. genetic changes, structural and numerical chromosome anomalies, are involved in pathogenesis of mm, and are among the most important prognostic factors of disease-associated patient survival. micrornas (mirnas) are small 19-22 nucleotide single-stranded rnas involved in important cellular processes. cyto...

MicroRNAs are small RNAs with ability to attach the large number of RNA that regulate gene expression on post-transcriptional level via inhibition or degradation specific mRNAs. MiRNAs in cells primary regulators functions such as cell growth, differentiation, and apoptosis considerably influence function. The levels microRNAs change human diseases, including cancer. These changes highlight the...

Tiny non-coding RNAs called microRNAs (miRNAs) are crucial for cell survival and differentiation. Numerous cancer varieties, including acute myeloid leukemia, have been linked to abnormal miRNA expression (AML). Objective:

Objective(s): MicroRNAs (miRNAs) are a subfamily of small noncoding RNAs that play a variety of roles in regulating gene expression in nearly all organisms. They affect different biological pathways by post-transcriptionally regulating mRNAs. Aside from miRNAs’  role in maintaining cellular homeostasis, their perturbation is related to several pathologic states and dis...

The importance of nanotechnology in medical technologies, especially biomedical diagnostics, is indubitable. By taking advantages of nanomaterials, many medical diagnostics methods have been developed so far, including electrochemical nanobiosensors. They have been used for quantification of different clinical biomarkers for detecting, screening, or follow up a disease. microRNAs (miRNAs) are o...

micrornas (mirnas) are short rna molecules which bind to target mrnas, resulting in translational repression and gene silencing and are found in all eukaryotic cells. approximately 2200 mirna genes have been reported to exist in the mammalian genome, from which over 1000 belong to the human genome. many major cellular functions such as development, differentiation, growth, and metabolism are kn...

downs syndrome (ds), or trisomy 21, is the most common genetic cause of cognitive impairment and congenital heart defects in the human population. to date, the contribution of micrornas (mirnas) in ds has not been investigated. bioinformatic analyses demonstrate that human chromosome 21 (hsa21) harbors five mirna genes mir-99a, let-7c, mir-125b-2, mir-155 and mir-802. mirna expression profiling...

Exercise training (ET) is an important non-drug adjuvant therapy against many human diseases, including cardiovascular diseases. The appropriate ET intensity induces beneficial adaptions and improves physiological function cardiopulmonary fitness. mechanisms of exercise-induced cardioprotective effects are still not fully understood. However, mounting evidence suggest that microRNAs (miRNAs) pl...

Bladder malignancy is viewed as the fifth most basic disease with expanded disorder and demise. As of late, incessant examinations showed that microRNAs are arising indicative biomarkers for bladder malignancy. Explicit miRNA profiles have been distinguished a few examples from patients MicroRNAs noncoding RNA particles around 23 nucleotides assume significant parts in different strides during ...