There is a pressing need for continuous purification of products of synthesis conducted in continuous-flow microreactors. An existing technique, micro free-flow electrophoresis (microFFE), could fulfill this niche if its resolving power for similar molecules was improved. MicroFFE continuously separates ions in the hydrodynamic flow by an electric field orthogonal to the flow. Here, we prove th...

Microreactors have become an efficient tool for many enzymatic reactions because the laminar fluid flow within microchannel enables precise process control, rapid mixing, and short residence time. This paper provides a systematic overview of application reaction kinetics mathematical modeling processes in microreactors. Rapid heat mass transfer high surface-to-volume ratio are usually reasons w...

We study microreactors with internal fields of posts as typical examples of structured microreactors to elucidate flow fields and their implications for mass transfer. Laser-induced fluorescence (LIF) visualization combined with image analysis is used to systematically quantify key features such as interfacial area, phase holdup and the characteristics of the post-wetting layer. The subsequent ...

Electrochemical microreactors, which have electrodes integrated into the flow path, can afford rapid and efficient electrochemical reactions without redox reagents due to the intrinsic properties of short diffusion distances. Taking advantage of electrochemical microreactors, Kolbe electrolysis of di-and trifluoroacetic acid in the presence of various electron-deficient alkenes was performed un...

The length of time that the solution remains inside the reactor channels—the residence time—can be greatly reduced by adjusting the length of the channels in flow microreactors. This feature is extremely useful in controlling reactive species. Unstable short-lived reactive species can be generated and transferred to another location to be used in the next reaction before they decompose. Therefo...

this study aimed to determine the aerosolization behavior of a nanodispersion of budesonide, prepared using microfluidic reactors. the size and morphology of budesonide nanoparticles were characterized by photon correlation spectroscopy (pcs) and transmission electron microscopy (tem). processing/formulation parameters for formation of the nanoparticles were studied to determine their effects o...

DNA computing is an interdisciplinary field accessing the possibility for the use of biomolecules, such as DNA, RNA and proteins, as a computational or control tool. Traditionally, DNA computers were thought to compete with electronic computers to solve, for example, NP-complete problems. However recently, there has been a focus shift to biomedical applications. One form of DNA computing is per...

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Aromatic aldehydes have been converted into the corresponding carbamoyl azides using iodine azide. These reactions have been performed safely under continuous flow reaction conditions in microreactors.

Miniaturization and silicon integration of micro enzyme reactors for applications in micro total analysis systems (μTASs) require new methods to achieve structures with a large surface area onto which the enzyme can be coupled. This paper describes a method to accomplish a highly efficient silicon microstructured enzyme reactor utilizing porous silicon as the carrier matrix. The enzyme activity...