conclusions algino-pectinate mucoadhesive formulations exhibited promising properties of a sustained release form for piroxicam and provided distinct tissue protection in stomach. objective the purpose of this research was to decrease gastric side effects of piroxicam by formulating microspheres of alginate and algino-pectinate beads of the drug. materials and methods ionotropic gelation was us...

This study examined the role of platelet microparticles in thromboxane A2 (TXA2) production. Incubation of microparticles with [14C]arachidonic acid and A23187 produced 14C-labeled TXB2, the stable metabolite of TXA2. To investigate the possibility that endothelial cells (ECs) transfer arachidonic acid to platelet microparticles and promote TXB2 synthesis, ECs with their cellular lipids prelabe...

heavy metals are highly poisonous in the environment, even in small quantities, and endanger certain species and all live beings. current methods of removing heavy metals from aqueous media include chemical sequestration, ion exchange, surface absorption, membrane processes, oxidation and revival procedures which have high investment and exploitation costs. hence, it is significantly necessary ...

Thymol, an important and advantageous component of many essential oils, has been applied as an antimicrobial agent in animals. To increase the duration of action of this compound in ruminants, it was decided here to prepare a controlled release carrier for thymol. Hydroxy propyl methyl cellulose (HPMC) and ethyl cellulose (EC) were used as the matrix polymer here. Mixtures of thymol with eight ...

BACKGROUND Absorption of antigens onto chitosan microparticles via electrostatic interaction is a common and relatively mild process suitable for mucosal vaccine. In order to increase the stability of antigens and prevent an immediate desorption of antigens from chitosan carriers in gastrointestinal tract, coating onto BSA loaded chitosan microparticles with sodium alginate was performed by lay...

Gamma (gamma)-irradiation is finding increasing use in the sterilization of pharmaceutical products. However, irradiation also might affect the performance of drug delivery systems. In this study, the influence of gamma-irradiation on the characteristics of chitosan microparticles was investigated. The diclofenac sodium was incorporated into chitosan microparticles by spray-drying method. The c...

OBJECTIVE Diabetic retinopathy is associated with progressive retinal capillary activation and proliferation, leading to vision impairment and blindness. Microparticles are submicron membrane vesicles with biological activities, released following cell activation or apoptosis. We tested the hypothesis that proangiogenic microparticles accumulate in vitreous fluid in diabetic retinopathy. RESE...

The present study involves preparation and evaluation of gastric-mucoadhesive microparticles with Metformin Hydrochloride as model drug for prolongation of gastric residence time. The microparticles were prepared by the emulsification solvent evaporation technique using polymers of Carbomer 934p (CP) and Ethylcellulose (EC). The microparticles were prepared by emulsion solvent evaporation metho...

thymol, an important and advantageous component of many essential oils, has been applied as an antimicrobial agent in animals. to increase the duration of action of this compound in ruminants, it was decided here to prepare a controlled release carrier for thymol. hydroxy propyl methyl cellulose (hpmc) and ethyl cellulose (ec) were used as the matrix polymer here. mixtures of thymol with eight ...

conclusions we believe that the sh state in chf patients may be associated with the impaired pattern of circulating emps, with the predominantly increased number of apoptotic-derived microparticles. background subclinical hypothyroidism (sh) is diagnosed biochemically by the presence of normal serum free thyroxine concentration, in conjunction with an elevated serum thyroid-stimulating hormone ...