The micronucleus test is a well-established DNA damage assay in human monitoring. The test was proposed as a promising marker of cancer risk/susceptibility mainly on the basis of studies on breast cancer. Our recent meta-analysis showed that the association between micronuclei frequency, either at baseline or after irradiation, and breast cancer risk or susceptibility, has been evaluated in few...

The aim of the present study was to establish the extent of in vitro radioresponse of lymphocytes among 62 healthy adults of both genders and to estimate the distribution of baseline micronuclei and radiosensitivity among individuals of the study population using the cytochalasin block micronucleus test. A younger study group consisted of 10 males (mean age, 22.4 years; range, 21-27) and 12 fem...

The genotoxic effect of endosulfan and the modulatory effect of vitamin C in growing albino rats were studied by bone marrow micronucleus assay. Seven days old male Wistar rats were treated with 3, 6, 9, 12mg/kg Endosulfan orally (10 pups/group),for up to 60 days, at intervals of 24h. For 2 more groups (n=10/group), Endosulfan 9mg/kg and 12mg/kg was administered along with vitamin C (20mg/kg). ...

To the Editor: I read the research findings of Basu et al. (1) with great interest. However, there are some points which should be discussed. The authors showed that the level of lymphocytes with micronuclei in control (unexposed) persons was extremely low (1.66%). For example, in some European nations it is between 7% and 18% (2-7), and the least is in Turkish subjects—2.8% (8). According to t...

To the Editor: I read the research findings of Basu et al. (1) with great interest. However, there are some points which should be discussed. The authors showed that the level of lymphocytes with micronuclei in control (unexposed) persons was extremely low (1.66%). For example, in some European nations it is between 7% and 18% (2-7), and the least is in Turkish subjects—2.8% (8). According to t...

In the present study the protective effects of Aegle mamelos fruit extract AMF were carried out in somatic cells of mice against doxyrubicin induced genotoxicity. Three different doses of Aegle Marmelos fruit extract were tested for the antimutagenicity using the micronucleus test in bone marrow cells of mice. The test compound doxyrubicin higher dose 16 mg/kg was injected intrapertioneally pri...

The presence of micronuclei in mammalian cells is related to several mutagenetic stresses. In order to understand how micronuclei emerge, behave in cells, and affect cell fate, we performed extensive time-lapse microscopy of HeLa H2B-GFP cells in the presence of hydroxyurea at low concentration. Micronuclei formed after mitosis from lagging chromatids or chromatin bridges between anaphase chrom...

Pleural malignant mesothelioma is an uncommon neoplasm usually associated with asbestos exposure. The increasing incidence of malignant mesothelioma cases involving individuals with low levels of asbestos exposure suggests a complex carcinogenetic process with the involvement of other cofactors. Cytogenetic studies revealed the complexity of the genetic changes involved in this neoplasm reflect...

The treatment of HeLa neoplastic cells with low frequency and intensity electromagnetic field has determined modifications of the micronuclei number, this impact being correlated with the application manner of the electromagnetic field (continuous or discontinuous). Thus, the continuous electromagnetic field has reduced the frequency of the micronuclei formation (2.91 ± 0.015 ‰), as compared to...

Oral cancer is the leading cause of cancer deaths, and its incidence is still rising, particularly in developing countries. The World Health Organization reports that oral cancer is the sixth most common cancer in males and tenth most common cancer in females.1 Early detection and prevention of oral cancer is the need of the hour to improve the prognosis. Genomic damage is considered as the mos...