Background: Tobacco use continues to be prevalent in our society. It contains many substances which are genotoxic in nature. The genotoxicity of these substances can be studied in human peripheral blood lymphocytes by estimating the average number of micronuclei (MN) by cytokinesis block micronuclei assay (CBMN assay). Aims and objectives: To find out whether there is a difference in genotoxici...

Objectives: To determine the frequency of micronucleated cells and micronuclei in oral submucous fibrosis patients and to compare with healthy individuals. Study design: Twenty patients with oral submucous fibrosis and twenty age-sex-matched healthy individuals as control group participated in this study. Exfoliated cells were obtained by scraping from right and left buccal mucosa and were scre...

Paternal exposures to cancer chemotherapeutics or environmental chemicals may have adverse effects on progeny outcome that are manifested in the preimplantation embryo. The objectives of this study were to determine the impact of paternal exposure to cyclophosphamide, an anticancer alkylating agent, on the formation, chromatin origin and function of micronuclei in cleavage stage rat embryos. Ma...

In the modern developing society, application of radiation has increased extensively. With significant improvement in protection practices, exposure to human could be minimized substantially, but cannot avoided completely. Assessment is essential for regulatory decision and medical management as applicable. Until now, cytogenetic changes have served surrogate marker been extensively employed bi...

Background: We intend to study the inhibitory effect of sulfur compound in Ramsar hot spring mineral on tumor-genesis ability of high natural background radiation. Objective: The radioprotective effect of sulfur compounds was previously shown on radiation-induced chromosomal aberration, micronuclei in mouse bone marrow cells and human peripheral lymphocyte. Ramsar is known for having the highe...

Clerodendrum viscosum is a traditionally used medicinal plant. The present study aimed to analyze detailed cytotoxic effect of the non-polar petroleum ether fraction (AQPEF) leaf aqueous extract C. Vent. (LAECV) in Allium cepa root tip cells. LAECV was fractionated with and tested for A. toxicity. Micronuclei, polyploidy, mitotic abnormalities were analyzed after AQPEF treatment. induced concen...

BACKGROUND Erythrocebus patas (patas) monkeys were used to model antiretroviral (ARV) drug in human immunodeficiency virus type 1-infected pregnant women. METHODS Pregnant patas dams were given human-equivalent doses of ARVs daily during 50% of gestation. Mesenchymal cells, cultured from bone marrow of patas offspring obtained at birth and at 1 and 3 years of age, were examined for genotoxici...

The appearance, after colchicine treatment, of cells containing large numbers of micronuclei also called chromosome-vesicles, idiomeres, karyo meres—has been observed by several authors in different biological materials. Brues and Jackson ( @) foundtheminregenerating rat liverandinter preted their formation to be due to the swelling of the individual chromosomes after mitosis has been arreste...

The appearance, after colchicine treatment, of cells containing large numbers of micronuclei also called chromosome-vesicles, idiomeres, karyo meres—has been observed by several authors in different biological materials. Brues and Jackson ( @) foundtheminregenerating rat liverandinter preted their formation to be due to the swelling of the individual chromosomes after mitosis has been arreste...