This paper presents an artificial intelligence monitoring system developed by the NASA Glenn Principal Investigator Microgravity Services project to help the principal investigator teams identify the primary vibratory disturbance sources that are active, at any moment in time, on-board the International Space Station, which might impact the microgravity environment their experiments are exposed...

In this report we describe the results of a continuous flow electrophoresis (CFE) experiment done on STS-65 in which we tested the idea that intracellular growth hormone (GH) particles contained in a cell lysate prepared from cultured rat anterior pituitary cells in microgravity might have different electrophoretic mobilities from those in a synchronous ground control cell lysate. Collectively,...

In the present study, we discovered that mouse oocyte maturation was inhibited by simulated microgravity via disturbing spindle organization. We cultured mouse oocytes under microgravity condition simulated by NASA's rotary cell culture system, examined the maturation rate and observed the spindle morphology (organization of cytoskeleton) during the mouse oocytes meiotic maturation. While the r...

Microgravity can affect many aspects of intestinal homeostasis, leading to an increased risk of colitis. Estrogen, the most frequently affected hormone when under simulated microgravity, regulates the permeability of the colonic mucosa barrier. The associations between alterations in intestinal microbiota and increased susceptibility under microgravity have not been thoroughly elucidated. The a...

NASA dedicated over 20 shuttle missions to microgravity research as a primary payload, and many more missions carried microgravity research experiments as secondary payloads. The space agency’s microgravity research strived to increase understanding of the effects of gravity on biological, chemical, and physical systems. Living systems benefited as well. Cells, as they adapted to microgravity, ...

background: revealing data on the role of vitamin d and calcium supplementation in bone health has led some to suggest that vitamin d and calcium treatment could also play a role in protecting bone against microgravity-induced mineral loss. objectives: the aim of the present study was to investigate the effects of vitamin d and calcium administration on microscopic and densitometric changes of ...