نتایج جستجو برای: micos model
تعداد نتایج: 2104453 فیلتر نتایج به سال:
The inner membrane (IM) of mitochondria displays an intricate, highly folded architecture and can be divided into two domains: the inner boundary membrane adjacent to the outer membrane and invaginations toward the matrix, called cristae. Both domains are connected by narrow, tubular membrane segments called cristae junctions (CJs). The formation and maintenance of CJs is of vital importance fo...
Mitochondria form a dynamic network that responds to physiological signals and metabolic stresses by altering the balance between fusion and fission. Mitochondrial fusion is orchestrated by conserved GTPases MFN1/2 and OPA1, a process coordinated in yeast by Ugo1, a mitochondrial metabolite carrier family protein. We uncovered a homozygous missense mutation in SLC25A46, the mammalian orthologue...
Thèse de doctorat financée dans le cadre de la convention FIRST Doctorat MINOS (Moteur d'INférence pour l'Optimisation de Structures) n° 001/4442 par la Région Wallonne et Samtech s.a. Résumé Ré–1 RÉSUMÉ
MINOS is a long baseline neutrino oscillation experiment designed to make precision measurements of the neutrino mixing parameters associated with the atmospheric neutrino mass splitting. Using a neutrino beam from the Main Injector (NuMI) facility at Fermilab, it compares the neutrino energy spectrum for neutrino interactions observed in two large detectors located at Fermilab and in the Souda...
Mammals C. elegans 1 TM domain; C-term in IMS and N-term in the matrix. IBM & CJ; self-oligomerizes, binds MICOS/MINOS/MitOS components and Sam50, Tob38, Ugo1, Fzo1. Yeast are viable but exhibit altered mtDNA inheritance and decreased respiratory growth. Mammals and worms exhibit increased ROS production and apoptosis. Loss of CJ, altered cristae structure, accumulation of cristae stacks and cr...
Oxidative phosphorylation takes place at specialized compartments of the inner mitochondrial membrane, the cristae. The elaborate ultrastructure of cristae membranes enables efficient chemi-osmotic coupling of respiratory chain and F1Fo-ATP synthase. Dynamic membrane remodeling allows mitochondria to adapt to changing physiological requirements. The mitochondrial contact site and cristae organi...
The mitochondrial inner membrane is highly folded and displays a complex molecular architecture. Cristae junctions are highly curved tubular openings that separate cristae membrane invaginations from the surrounding boundary membrane. Despite their central role in many vital cellular processes like apoptosis, the details of cristae junction formation remain elusive. Here we identify Mic10, a co...
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