نتایج جستجو برای: mice bax and bcl 2 genes real time pcr brain

تعداد نتایج: 17613575  

Background: Cancer treatment methods can lead to male infertility .in this regard, cryopreservation of spermatogonial stem cells (SSC) and cell-to-person transplantation after the course of treatment to resolve the problem of infertility is a good one. The cryopreservation of SSC is an important process as it can help on the return of spermatogenesis. However, during this process, the stem cell...

Introduction: Busulfan as a chemotherapeutic agent causes testicular germinal epithelium depletion and cytotoxicity in germ cells. The aim of this study was to assess antioxidant status, reactive oxygen species (ROS) generation and apoptosis-related genetic markers of adult male mouse sperm following busulfan treatment. Materials and Methods: Forty adult NMRI mice (30 ± 5 g) were divided...

Masoud Salehipour, Parisa Alaei, Parvin Khodarahmi,

Background and Aims: Cadmium is an important environmental pollutant and a potent toxicant to organisms. However, the toxicity of Cadmium and its influences on stomach is still unclear. We examined the effects of intraperitoneal injection of Cadmium on mRNA expression of Bcl-2 and Bax genes in rat stomach. Materials and Methods: Twenty eight male Wistar rats weighing 200 to 250 g were randomly...

Ardalan, Touran , Neamati, Ali Neamati, Yousefi Rad, Hadiseh ,

Introduction: There are different treatment methods for cancer therapy, including surgical, anatomy, biopsy, chemotherapy and radiotherapy, but the side effects of these methods as well as their inefficiency for complete omission of cancer have led researchers to find a way to safety remove cells and cancerous tumors. The aim of this study was evaluation of cytotoxicity effects and apoptotic pr...

Journal: :Annals of Cancer Research and Therapy 2021

Currently, it has been suggested that human mesenchymal stem cells (MSCs), a well-known multipotent cells, could modify the biological process in leukemia cells. Therefore, we evaluated MSCs’ possible effects on apoptosis and proliferation of acute lymphoblastic (ALL) MOLT-4 Accordingly, were co-cultured with MSCs. Then, 24, 48, 72 hours after treatment, percentages cell was estimated using flo...

Journal: :caspian journal of internal medicine 0
mozhgan moazami-goudarzi stem cell research center, tabriz university of medical science, tabriz, iran majid farshdousti-hagh hematology and oncology research center, tabriz university of medical science, tabriz, iran abbasali hoseinpour-feizi hematology and oncology research center, tabriz university of medical science, tabriz, iran mehdi talebi hematology and oncology research center, tabriz university of medical science, tabriz, iran ali-akbar movassaghpour-akbari hematology and oncology research center, tabriz university of medical science, tabriz, iran karim shams-asanjan hematology and oncology research center, tabriz university of medical science, tabriz, iran

background: bcl-2 is the most important anti-apoptotic regulator and bax is a pro-apoptotic protein. the status of these parameters or the ration of bcl-2 to bax is important in malignant cell fate as well as normal cells. methods: sixty-two all patients and 62 healthy sex-and age-matched controls were studied. after genotyping, the promoter region of the bax and bcl-2 genes by rflp-pcr method ...

Background & Aims: Plant extracts can change the expression of genes in cancer cells. Till now, no study has been performed on the effect of algae extract. The aim of this research was to study the changes in Bax apoptotic gene expression in glioblastoma cell line and to determine the rate of cell death in cancer cells treated with Dunalilla salina extract. U87 cell line contains glioblas...

پایان نامه :وزارت علوم، تحقیقات و فناوری - پژوهشگاه ملی مهندسی ژنتیک وزیست فناوری 1391

بتاکربولین آلکالوئید ها مانند هارمین و هارمالین از عمده ترین آلکالوئید های موجود در دانه ی اسپند peganum harmala l می باشند که به دلیل نقش احتمالی آنها در درمان سرطان مورد توجه قرار گرفته اند. تاثیر آلکالوئید های مذکور پس از استخراج و شناسایی در مهار رشد سلول های سه رده ی سرطانیmda_mb_231 ، skbr-7 و sknmc مورد بررسی قرار گرفتند.تغییرات مورفولوژیکی و وقوع آپپتوز توسط کیت آنکسین مورد ارزیابی قرار...

Absalan F, Movahedin M Mowla SJ

Background: Experimental cryptorchidism is a common model for examining the expression and function of heat-induced spermatogenesis related genes in testis. In this study the expression of genes & proteins thatinvolved in programmed cell death after treatment of cryptorchidism was examined. Materials and Methods: To induce bilateral cryptorchid model immature mice were anesthetized and a small ...

Journal: :iranian biomedical journal 0
معصومه عبدالهی maasoume abdollahi مژده صالح نیا mojdeh salehnia ساغر صالح پور saghar salehpour نسیم قربانمهر nassim ghorbanmehr

background: in this study, we evaluated the incidence of apoptosis at the ultrastructural levels and expression of some apoptosis-related genes in vitrified human ovarian tissue just after warming. methods: human ovarian tissue biopsies from 23 women after caesarean section were transported to the laboratory within 2 hours, and then they were cut into small pieces. some pieces were vitrified an...

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