Miltefosine (MFS) is an alkylphosphocholine used for the local treatment of cutaneous metastases of breast cancer and oral therapy of visceral leishmaniasis. Recently, the drug was reported in in vitro and preclinical studies to exert significant activity against different developmental stages of schistosomiasis mansoni, a widespread chronic neglected tropical disease (NTD). This justified MFS ...

Charcoal burning has emerged as a novel suicide method in Taiwan and its impact on maternal filicide-suicide (MFS) remains unexplored. Using official national mortality data and reports of MFS cases from electronic newspaper archives, the authors aimed to examine whether the newly available charcoal burning was associated with an increase in MFS incidents during the period from 1999 to 2006. Th...

AIM The aim of this study was to determine the correlations among hippocampal damage, spontaneous recurrent seizures (SRS), and mossy fiber sprouting (MFS) using pentylenetetrazole (PTZ) kindling model. METHODS Chronic epileptic model was established by administration of PTZ. Behaviour and EEG seizure activity were recorded. Rats' hippocampus were analyzed with haematoxylin and eosin (H&E) st...

marfan’s syndrome (mfs) is a genetic disorder associated with autosomal dominant inheritance. in mfs, the most prevalent cause of death is cardiovascular involvement. here we introduce a family with a severe penetration of mfs. eleven members of this family have mfs (father, two daughters, three sons, and five grandchildren). the most common cardiac involvement in our patients was mitral valve ...

Power stations produce a range of magnetic fields more than 20 mT which are harmful to those working or living around them. Several investigators have reported an increased health risk due to exposure to electric and magnetic fields (EMF) at 50 and 60 Hz. Several studies have been reported especially with increased tumor incidence, effects on reproduction and development, and neural and behavio...

BACKGROUND Marfan syndrome (MFS) and familial non-syndromal thoracic aortic aneurysm and dissection (ns-TAAD) are genetic aortopathies causing aortic dilatation with increased aortic stiffness. Left ventricular (LV) contractility and ventricular-vascular coupling index (VVI) were compared between MFS and ns-TAAD and determinants of VVI were investigated. METHODS AND RESULTS Patients with MFS ...

BACKGROUND Marfan syndrome (MFS) is a pleiotropic genetic disorder with major features in cardiovascular, ocular and skeletal systems, associated with large clinical variability. Numerous studies reveal an involvement of TGF-β signaling. However, the contribution of tissue inflammation is not addressed so far. METHODOLOGY/PRINCIPAL FINDINGS Here we showed that both TGF-β and inflammation are ...

The real magnetic fields (MFs) acting on graphene can induce flat Landau levels (LLs). As an analogy, strains in produce significant pseudo MFs, triggering the appearance of dispersive LLs. By analyzing low-energy effective Hamiltonian, we introduce concept orbital MFs to integrate and MFs. Accordingly, obtain complex LLs which incorporate LLs, calculate related transport properties. These conc...

1.1 Definition and prevalence Marfan syndrome (MFS) is an autosomal dominant connective tissue disorder involving the cardiovascular, skeletal and ocular systems, the integument, lungs and dura. Cardinal manifestations include aortic aneurysm and dissection, ocular lens dislocation and long bone overgrowth. In 90-93% of cases, MFS is caused by mutations in FBN1. Mutations in a second gene, TGFB...

Marfan syndrome (MFS, MIM #154700) is an autosomal dominant disorder of the extra cellular matrix affecting the connective tissue with cardiovascular, skeletal, neurological, integumental and ocular abnormalities.1 More than 85% of MFS cases are causally linked to mutations in the fibrillin-1 gene (FBN1, 15q21.1). In 1994, a second locus (MFS2) (MIM #154705) was found to map at 3p25–p24.22 afte...