Dutch elm disease is caused by the fungal pathogen Ophiostoma novo-ulmi which is transmitted by the native elm bark beetle, Hylurgopinus rufipes. We have found that four semiochemicals (the monoterpene (-)-beta-pinene and the sesquiterpenes (-)-alpha-cubebene, (+)-spiroaxa-5,7-diene and (+)-delta-cadinene) from diseased American elms, Ulmus americana, synergistically attract H. rufipes, and tha...

The title compound, C(20)H(26)NO(2) (+)·Br(-), is an N-chiral quaternary ammonium salt synthesized from (2S*)-N-benzyl-N-methyl-tyrosine methyl ester. The dihedral angle between the phenyl ring and the benzene ring is 11.61 (19)°. In the crystal structure, the allyl group is disordered over two positions with site occupancy factors of ca 0.8 and 0.2. The bromide anion links to the quaternary am...

' 2004 Canadian Medical Association A woman, weighing 121 kg, presented with blurred vision. On examination, her blood pressure was 210/160 mm Hg. The physical examination was otherwise unremarkable. She was found to have elevated urinary dopamine, normetanephrine and total metanephrine levels. Magnetic resonance imaging (Fig. 1 and Fig. 2) demonstrated a dumbell-shaped tumour, measuring 4.0 × ...

Adrenal diseases comprise for a variety of medical endocrine issues, ranging from partial or complete gland insufficiency, to several kinds of adrenal hyperfunction, either of congenital or neoplastic etiology. For hypofunction of the adrenals (partial or complete) the treatment of choice is medical; the mainstay of treatment is hydrocortisone. Patients with congenital adrenal hyperplasia cause...

Disturbances of the sympathetic nervous system (SNS) have been described in chronic renal failure, but their role in the metabolic derangements of uremia has not been well established. In these studies, SNS activity has been measured in the ventromedial hypothalamic (VMH) nuclei and in the intercostal brown adipose tissue (IBAT) of Sprague Dawley 5/6 nephrectomized or sham-operated rats. SNS ac...

The involvement of D-1 and D-2 dopamine (DA) receptors in mediating the DA regulation of preprotachykinin (PPT) gene expression was investigated in rat striatal tissue. Initial experiments determined that acute treatment with the indirect DA agonist methamphetamine induces increases in total PPT messenger RNA, with a maximal effect seen within 3 hr. RNA protection studies established that acute...

cal Hazards, Faculty of Pharmaceutical Sciences, University of Tokyo, Bunkyo-ku, Tokyo. The mechanism of the development of tolerance to and of physical dependence on morphine has been examined from a wide range of aspects. One of the approaches is to investigate the participation of brain biogenic amines in the actions of morphine. In 1954 Vogt (1) found a reduction of the content of hypothala...

The role of renal nerves in influencing the control of arterial pressure was studied in Wistar rats with aortic depressor nerve (ADN) transection. Renal denervation prevented or reversed the normal increase in arterial pressure seen after ADN transection. This effect was not due to an effect on the renin-angiotensin system, as the elevated arterial pressure after ADN section in rats with renal ...

The effect of morphine administration on the subsequent stimulation of prolactin (PRL) secretion and the release of dopamine from tuberoinfundibular neurons was examined in this study. The administration of morphine (15 mg/kg s.c.) resulted 4 hr later in suppressed serum PRL concentrations. In addition, the increase in serum PRL concentrations induced by restraint stress was attenuated greatly ...