1Department of Pharmaceutics, SriVenkateshwara College of Pharmacy and Research center, Affiliated to Osmania University, Madhapur, Hitech City, Hyderabad500081,Andhra Pradesh, India. A b s t r a c t Sitagliptin phosphate when used alone is an oral anti hyperglycemic drug of the dipeptidyl peptidase-4 (DPP-4) inhibitor class. It is available as tablets under trade name JANUVIA. Metformin hydroc...

This work deals with the simultaneous estimation of metformin hydrochloride and pioglitazone hydrochloride in a bilayered tablet dosage form, without prior separation by two techniques. The methods employed are derivative spectrophotometery and Q analysis. The absorption maxima at 231 nm and 269 nm were used for the estimation of metformin and pioglitazone, respectively. Both the drugs and thei...

In the presented case, we got an herbal medicine in the form of a set of different color pills from local herbal medicinal practitioner. According to the advertisements on monograph, the product contains only herbal ingredients without any adequate declaration of the ingredients and was declared as anti-diabetic formulation. For identification of the ingredients, the pills were analyzed by UV, ...

Metformin hydrochloride is an oral antidiabetic biguinide agent, used in the management of non-insulin-dependent (type-2) diabetes mellitus. The purpose of present work was to formulate tasteless complexes of metformin hydrochloride with indion 234 and to evaluate molecular properties of drug complexes. The drug loading onto ion-exchange resin was optimized for mixing time, activation, effect o...

The focus of this study is to develop and validate a HPLC method to simultaneously estimatemetformin hydrochloride and canagliflozin in bulk using GraceSmart RP-18 column (250× 4.6mm, 5μ)at 30°C.Combination of acetonitrile(ACN) and ammonium acetate bufferin the ratio of 45:55v/v with pH 4.5 was used as mobile phase with 1ml/min flow rate. It was detected by photo diode array detector at 252 nm....

Two simple, precise and economical UV methods have been developed for the simultaneous estimation of Sitagliptinphosphate Metformin hydrochloride in bulk pharmaceutical dosage form. Method A is Absorbance maximamethod,whichisbasedonmeasurementofabsorptionatmaximumwavelengthof266nmand232nmforSitagliptinphosphateandMetforminhydrochloriderespectively.MethodBisareaundercurve(AUC),inthewavelength ra...

the present study involves preparation and evaluation of gastric-mucoadhesive microparticles with metformin hydrochloride as model drug for prolongation of gastric residence time. the microparticles were prepared by the emulsification solvent evaporation technique using polymers of carbomer 934p (c) and ethylcellulose (ec). the microparticles were prepared by emulsion solvent evaporation method...

The chromium (III) metformin hydrochloride complex as a diabetic drug model was synthesised by the chemical reaction between chromium (III) chloride hexahydrateand metforminHCl (Mfn.HCl) in methanol solvent. The [Cr(Mfn-HCl)2(Cl)2].Cl.6H2O complex was characterized using microanalytical measurements, molar conductance, spectroscopic (infrared, and UV-vis.), effective magnetic moment, and therma...

diabetes is a metabolic disorder which affects whole body systems including reproductive system. diabetes is also a contributing factor to infertility. metformin is one of the most common drugs to control hyperglycemia. in this study, 36 adult sprague-dawley female rats (170-210 g) were divided into 3 groups (control, diabetic and diabetic-treated by metformin). in second and third groups, diab...

A simple, selective, rapid and economical reversed phase high performance liquid chromatographic method for the determination of metformin hydrochloride in bulk and dosage forms has been developed and validated. The separation was carried out on a Discovery reversed phase C-18 column (250 mm x 4.6 mm, 5.0 μm) with UV detection at 233 nm. The mobile phase contained 34% acetonitrile and 66% aqueo...