abstract purpose: metastatic breast cancer has remained as an incurable disease. the main objectives of treatments include alleviating of symptoms, delaying disease progression and increasing survival without any adverse effect on the quality of life. the main purpose of this study was to investigate the effects of some clinocopathological factors on the survival of patients with metastatic bre...

metastatic   tumors in the nose and paranasal sinuses are infrequent. the origin of this metastatic tumors are often renal cell carcinoma. we present one case of metastatic renal cell carcinoma   to the nose and paranasal sinuses ,4 years after initial nephrectomy and diagnosis of stage t1n0m0 clear cell carcinoma. the patient complained of nasal obstruction and recurrent epistaxis   who was tr...

SUMMARY Ten cases of cystic meningioma are reported and the literature is reviewed. The cyst formation with meningioma is rarely seen and are frequently associated with glial or metastatic tumor. The computerized tomography appearance of our cases also resembling glial and metastatic appearance of our cases also resembling glial and metastatic tumor. The incidence of microcystic and cystic cha...

Renal cell carcinoma (RCC) is an aggressive malignancy which can metastasize to the bone. Long bones or the small bones of the limbs could be rarely the destinations for metastatic RCCs. We report two cases of metastatic RCC to the humerus bone with the initial presentation of pathological fracture. The pathologists must be aware of metastatic RCC to the arm and consider it in the differential ...

cytokines influence cell cycle events, which in some but not all instances can be associated with melanoma progression. analysis of the g0/g 1 and s phase fractions of the cell cycle was used to assay the proliferative or inhibitory activity of cytokines against ten human melanoma cell lines, including pairs of cell lines derived from primary and metastatic tissue of individual patients. cytoki...

Introduction: Metastatic lesions of the oral cavity are extremely rare, accounting for approximately 1% of all malignant oral tumors. The most common primary sources of metastatic tumors in the oral region are, from the most to the least common, the breast, lung, kidney, bone, and colon. Renal cell carcinoma accounts for nearly 3% of all adult malignancies. It usually metastasizes to the lungs,...

Background & objective:Primary pleural neoplasms are rare entities compared with the pleural involvement by metastatic carcinoma. The current study aimed at investigating the complete spectrum of pleural neoplasms and differentiating between them with the aid of immunohistochemistry (IHC). Methods: Consecutive pleu...

Background: CD4+ and CD8+ T cells are the main types of lymphocytes in cell-mediated immunity and play a central role in the induction of efficient immune responses against tumors. The frequencies of T cell subtypes in the peripheral blood and tumor tissues, and draining lymph nodes (dLN) can be considered as useful markers for evaluation of the immune system in cancers. Methods: In this study,...

Introduction: Cauda equina secondary to metastatic follicular thyroid cancer of the lumbosacral area is a rare entity.   Case Report: We report an unusual case of a 52-year-old male who presented with backache, lower limb weakness, and perianal numbness. A CT-scan of the lumbosacral area showed an enhancing mass at the L4, L5 and S1 vertebrae. Histopathology after excision revealed a metast...

Prognosis of metastatic breast cancer is very poor which urges the necessity to develop novel potential drug candidates. We assessed two compounds with tri-aryl structures (A and B) for their potency to reduce primary breast tumor growth and lung metastasis in 4T1 mice model. MTT assay, 4T1 mammary mouse model and immunohistochemistry experiments were used in this study. In vitro results exhibi...