the adhesive interaction between tumor cells and the host cells or the extracellular matrix plays a crucial role in tumor metastasis. to evaluate the mediation of cell adhesion by daphne mucronata, an anti-cancer medicinal plant in iranian folk medicine, the adhesion of thrombin activated human platelets to the cultured monocytes or hl-60 cells was investigated under the effect of the plant ext...

purpose: to report a case of metastatic tumor to the right upper eyelid originating from a lung adenocarcinoma without any systemic signs. case report: a 68-year-old man had a two-month history of painless swelling in the right upper eyelid. the tumor slowly grew. two years before his presentation, he had received chemotherapy for lung cancer for one year. systemic and ocular examinations were ...

the paranasal sinuses are known to be a rare location for metastasis. renal cell carcinoma (rcc) is the most frequent primary tumor to metastasize to the sinonasal region, followed by lung and breast cancer. in particular, clear cell type rcc, which represents approximately 85% of rccs, is characterized by early metastasis, and it sometimes spreads to unusual sites (1, 2). metastatic tumors in ...

background: metastasis is one the most leading cause of death from cancer. the chemokine receptor of cxcr4 has an important role in cell migration and cancer metastasis. additionally, metastasis is always associated with the process of epithelial-mesenchymal transition (emt). in this study the correlation between expression of cxcr4 and emt-tfs has been examined. methods: the expression of cxcr...

despite the high rate of prostate cancer, the incidence of penile metastasis originating from prostate cancer is extremely rare, especially in the form of peyronie’s disease. moreover, brain metastasis, which is caused by prostate cancer, is not a common phenomenon and occurs mostly in older patients. herein, we report a case of a middle-aged man with penile and brain metastasis originating fro...

it has been reported that cxcl12 binding to cxcr4 induces several intracellular signaling pathways, and enhances survival, proliferation, and migration of malignant cells. herein we examined the effects of anti-estrogen tamoxifen and anti-allergic tranilast drugs as a single or in combination on invasion by two in vitro invasion assays, wound-healing and matrigel invasion on mcf-7 and mda-mb-23...

adenosquamous carcinomas of stomach are rare entities comprising 0.5% of stomach carcinomas. here, we report a case of a 50-year-old female, who presented with weakness, pallor, and symptoms of gastric outlet obstruction. a partial gastrectomy was done and histology showed evidence of adenosquamous carcinoma of the antrum with metastasis to the perigastric lymph nodes. the patient condition imp...

malignant tumors of pancreas are usually primary neoplasms and pancreatic metastases are rare findings. we are reporting a case of squamous cell carcinoma (scc) of the esophagus with pancreatic metastasis. a 59-year old woman was admitted with chief complaint of abdominal pain and mass. she was a known case of esophageal scc since 4 years before when she had undergone transthoracic esophagectom...

the presence of a low level of m protein in the peripheral blood