Citation: Waska H, Koschinsky A and Dittmar T (2016) Feand Cu-Complex Formation with Artificial Ligands Investigated by Ultra-High Resolution Fourier-Transform ion Cyclotron Resonance Mass Spectrometry (FT-ICR-MS): Implications for Natural Metal-Organic Complex Studies. Front. Mar. Sci. 3:119. doi: 10.3389/fmars.2016.00119 Feand Cu-Complex Formation with Artificial Ligands Investigated by Ultra...

Some general properties of the enzyme, ATPlombricine phosphotransferase (lombricine kinase), which catalyses the reaction: forward ATP + lombricine I-=_ ADP reverse + phospholombricine were described by Gaffney, Rosenberg & Ennor (1964). In common with other ATP-guanidino phosphotransferases (Ennor & Morrison, 1958) this enzyme is activated by Mg2+, Mn2+, Ca2+ and Co2+ ions. The role of the act...

Abstract New N2O2 type Schiff base has been designed and synthesized by condensing 2,4 dihydroxy benzaldehyde and α-naphthylamine in ethanol. Solid metal complexes of the schiff base with Cu(II), Ni(II) and Zn(II) metal ion were synthesized and characterized by elemental analysis, magnetic susceptibility, molar conductance, IR, UV-Vis and ‘H NMR spectral studies. The data shows that the c...

The ability of a carboxylic acid functionalized spiropyran, SP, to act as a reversible and selective receptor for metal ions has been systematically examined. A series of spectroscopic measurements, combined with single-crystal X-ray diffraction have been employed in order to determine metal-ion sensitivity and selectivity, binding constants, solution compositions, binding kinetics as well as s...

The nuclease domain of ColE7 (N-ColE7) contains an H-N-H motif that folds in a beta beta alpha-metal topology. Here we report the crystal structures of a Zn2+-bound N-ColE7 (H545E mutant) in complex with a 12-bp duplex DNA and a Ni2+-bound N-ColE7 in complex with the inhibitor Im7 at a resolution of 2.5 A and 2.0 A, respectively. Metal-dependent cleavage assays showed that N-ColE7 cleaves doubl...

While it is evident that a metal ion in aqueous solution interacts electrostatically with water molecules and the anions present in the solution, it is equally apparent that often the metal ion chemically combines with varying numbers of ions or molecules to form complex species. This tendency towards coordination complexing is observed most often with the transition metals and results in a ser...

Metals such as platinum, gold, ruthenium, titanium and tin can be a source of biologically active derivatives and, occasionally, become tools in the chemotherapy against different kinds of human tumors. The preclinical evaluation includes not only antitumor activity tests but also the investigation of the particular chemistry, the molecular targets within biological materials and the effect on ...

The safe decomposition of solid TATP (triacetone triperoxide) explosive is examined theoretically. The route to destruction starts with formation of metal complexes between a metal ion and the TATP molecule. The second step is decomposition of the molecules into stable final products. We examined the structure and stability of both metal ion (including Na(+), Cu(+), Cu(2+), Co(2+), and Zn(2+)) ...

Partly due to lack of detailed knowledge of the molecular recognition of ligands the structural basis for partial versus full agonism is not known. In the beta(2)-adrenergic receptor the agonist binding site has previously been structurally and functionally exchanged with an activating metal-ion site located between AspIII:08-or a His residue introduced at this position in transmembrane domain ...

The bacterial phosphotriesterase (PTE) from Pseudomonas diminuta catalyzes the hydrolysis of organophosphate esters at rates close to the diffusion limit. X-ray diffraction studies have shown that a binuclear metal center is positioned in the active site of PTE and that this complex is responsible for the activation of the nucleophilic water from solvent. In this paper, the three-dimensional st...