BACKGROUND Little is known about the global magnitude of mesothelioma. In particular, many developing countries, including some with extensive historical use of asbestos, do not report mesothelioma. OBJECTIVES We estimated the global magnitude of mesothelioma accounting for reported and unreported cases. METHODS For all countries with available data on mesothelioma frequency and asbestos us...

conclusion ct scan is highly accurate in differentiating malignant pleural mesothelioma and metastatic pleural diseases. pleural thickening and thickening of interlobar fissure lead us to the diagnosis of mpm and massive free pleural effusion is more commonly seen in metastatic pleural malignancy. background malignant pleural mesothelioma (mpm) is a rare malignant neoplasm of the pleura that ty...

Localized malignant pleural mesothelioma (LMPM) is a rare cancer with poor survival rates. Often affecting males asbestos exposure, we report case of 56-year-old female no history occupational exposure presenting worsening cough. A radiological examination revealed left effusion and thickening. Cytological pathological reports samples were consistent epithelioid type, the histological via video...

Malignant pleural mesothelioma is a poorly treated neoplasia arising from the pleural mesothelial lining. Here we document that the leaf extract of Cynara scolymus exerts broad antitumoral effects both in vitro and in vivo on mesothelioma cell lines. We found that Cynara scolymus treatment affects strongly cell growth, migration and tumor engraftment of mesothelioma cell lines. Strikingly, diet...

The pathetic malignant mesothelioma (MM) is a extremely uncommon and confrontational tumor that evolves in the mesothelium layer of pleural cavities (inner lining- visceral pleura outer parietal pleura), peritoneum, pericardium, tunica vaginalis highly resistant to standard treatments. In mesothelioma, predominant pattern lesions loss genes limit tumour growth. Despite worldwide ban on manufact...

AIMS AND BACKGROUND Malignant mesothelioma is a fatal cancer of increasing incidence in north-eastern Italy. Together with asbestos, the polyomavirus SV40 was hypothesized to contribute to the onset of malignant mesothelioma. To investigate the putative role of SV40 in the individual susceptibility to asbestos-induced malignant mesothelioma, we conducted a molecular epidemiological study on a s...

Like many tumors, malignant mesothelioma exhibits significant chemoresistance and resistance to apoptosis in vivo that is not seen in current in vitro models. To study the mechanisms of this multicellular resistance, biologically relevant in vitro models are necessary. Therefore, we characterized and tested human mesothelioma tissue grown in vitro as tumor fragment spheroids. After 5-10 d in cu...

In the United States, mesothelioma, a rare cancer, is estimated to occur in approximately 2,500 people annually [1]. Sporadic cases have been reported in Korea. Although, malignant pleural mesothelioma is the most common type of mesothelioma, mesothelioma has also observed in the peritoneum and pericardium. Malignant pleural mesothelioma is observed mainly in older men (median age, 72 years) wh...

Malignant Mesothelioma, or mesothelioma, is a mesothelial-based malignancy that may occur in the pleura, pericardium and peritoneum. Mesothelioma is a very aggressive cancer with limited treatment, and a median survival of about 1 year. At times, the diagnosis of mesothelioma may be problematic. The final diagnosis of mesothelioma relies on histology and often is dependent upon immunohistochemi...

To assess the presence of SV40 in malignant mesothelioma tissue, 19 formalin-fixed paraffin-embedded pleural cancer samples of patients from a hyperendemic area of northeastern Italy were analyzed retrospectively. A total of 48 other tissues from the malignant mesothelioma subjects were investigated. The SV40 load was determined by real-time quantitative PCR. Exposure to asbestos was evaluated ...