Semantic interoperability between electronic health record systems and other information systems in the health domain implies agreement about the structure and the meaning of the information that is communicated. There are still a number of similar but different EHR system approaches. Some of the newer approaches adopt the two-layer model approach where a generic reference model is constrained ...

While HL7 CDA is a widely adopted standard for the documentation of clinical information, the archetype approach proposed by CEN/ISO 13606 and openEHR is gaining recognition as a means of describing domain models and medical knowledge. This paper describes our efforts in combining both standards. Using archetypes as an alternative for defining CDA templates permit new possibilities all based on...

Biological systems that perform multiple tasks face a fundamental trade-off: A given phenotype cannot be optimal at all tasks. Here we ask how trade-offs affect the range of phenotypes found in nature. Using the Pareto front concept from economics and engineering, we find that best-trade-off phenotypes are weighted averages of archetypes--phenotypes specialized for single tasks. For two tasks, ...

This work discusses the modeling of clinical data using openEHR archetypes. The openEHR project aims at developing an open and interoperable health computational platform, and an important component in this effort is the development of electronic health records (EHRs) that are clinically effective and interoperable. The project publishes specifications, implementations and archetypes with that ...

The creation of fictional stories is a very complex task that usually implies a creative process where the author has to combine characters, conflicts and plots to create an engaging narrative. This work presents a simulated environment with hundreds of characters that allows the study of coherent and interesting literary archetypes (or behaviours), plots and sub-plots. We will use this environ...

To enable the efficient reuse of standard based medical data we propose to develop a higher level information model that will complement the archetype model of ISO 13606. This model will make use of the relationships that are specified in UML to connect medical archetypes into a knowledge base within a repository. UML connectors were analyzed for their ability to be applied in the implementatio...

Given a collection of data points, non-negative matrix factorization (NMF) suggests to express them as convex combinations of a small set of ‘archetypes’ with non-negative entries. This decomposition is unique only if the true archetypes are non-negative and sufficiently sparse (or the weights are sufficiently sparse), a regime that is captured by the separability condition and its generalizati...

The current state of nuclear fuel cycle simulation exists in highly customized form. Satisfying a wide range of users requires model modularity within such a tool. Cyclus is a fuel cycle simulator specifically designed to combat the lack of adaptability of previous generations of simulators. This is accomplished through an agent-based infrastructure and treating time discretely. The Cyclus kern...