Both aging and age-associated neurodegenerative diseases are related with various degrees of behavioral impairments, and among the prime candidates responsible for producing the neuronal changes mediating these behavioral deficits, appear to be free radicals and the oxidative agents which they generate. Free radicals such as vit. E may be important factors in maintaining neuronal integrity and ...

Objective. To study the effect of immunomodulators on learning and memory and on cholinergic receptor sensitivity. Methods. Animals were initially treated for a period of 8 days with cyclosporine/levamisole/saline. They were then subjected to passive avoidance training and 48 hrs later, the retention test for the passive avoidance task was conducted. Twenty-four hours after the retention tests ...

background: it has been known that brain-derived neurotrophic factor (bdnf) is involved in neural survival and long term memory (ltm). here we hypothesized that bdnf as a potent neurotrophic factor might modulate amnestic effect induced by morphine. objectives: the aim of this study was to examine whether infusion of exogenous bdnf in the ca1 regions of the dorsal hippocampi could ameliorate me...

objective(s): due to the prevalence and pervasiveness of stress in modern life and exposure to both chronic and acute stresses, it is not clear whether prior exposure to chronic stress can influence the impairing effects of acute stress on memory retrieval. this issue was tested in this study. materials and methods: adult male wistar rats were randomly assigned to the following groups: control,...

diabetes mellitus is accompanied with disturbances in learning, memory, and cognitive skills in the humans and experimental animals. due to the anti-diabetic and antioxidant activity of pelargonidin (pg), this research study was conducted to evaluate the efficacy of chronic oral pg on alleviating learning and memory disturbance in streptozotocin-diabetic rats. male wistar rats were divided into...

there are several conflicting evidences showing the effect of morphine on learning and memory processes. in the present study the effect of chronic morphine administration on passive avoidance, active avoidance and spatial learning and memory of morphine dependent male rats using passive avoidance shuttle box and morris water maze tasks were investigated, respectively. male rats received morphi...