The aim of this study was to evaluate the safety, tolerability and pharmacokinetics of single dose of Melissa officinalis extract which contained rosmarinic acid, including food-effects in healthy individuals. A total of eleven healthy individuals were randomly assigned to treatment arms in the two studies [Study 1 (fasted state) and Study 2 (fed state)]. Rosmarinic acid in serum was measured b...

Botanicals are an alternative option to prescription drugs for the alleviation of symptoms due to anxiety disorders and insomnia. Melissa officinalis L. has been shown as an anti-stress and anxiolytic agent. We previously reported moderate stress improvement in mice in which Cyracos(®), a standardized Melissa officinalis L. extract, was administrated. Cyracos(®) contains phytochemicals that inh...

This research investigated the effects of exogenous sodium nitroprusside (SNP) supplementation as nitric oxide (NO) on alleviating Pb-induced oxidative damage in lemon balm (Melissa officinalis L.) plants. Pb (100, 300 and 500 μM) alone and in combination with SNP (100 and 200 μM) were given to hydroponically grown Melissa officinalis L. plants. The findings suggested that in Pbtreated plants, ...

OBJECTIVE The aim of the present study was to investigate the neuroprotective effects of Melissa officinalis, a major antioxidant plant, against neuron toxicity in hippocampal primary culture induced by 3,4-methylenedioxymethamphetamine (MDMA) or ecstasy, one of the most abused drugs, which causes neurotoxicity. MATERIALS AND METHODS 3-(4,5-dimethyl-2 thiazoyl)-2,5-diphenyl-tetrazolium bromid...

The objective of this study was to determine the effect of a Melissa officinalis and Passiflora caerulea infusion on the severity of physiological chronic stress induced by movement restriction in CF-1 mice. 40 CF-1 male mice, six weeks of age, were divided into 4 groups (n = 10 for each group): (1) Group RS/MP received two treatments, induced stress through movement restriction and a infusion ...

Alzheimer's disease (AD) is a neurodegenerative disease that was characterized with deposit of beta amyloid (Aβ) aggregate in senile plaque. Oxidative damage to neurons and loss of cholinergic neurons in forebrain region are observed in this disease. Melissa officinalis is a medicinal plant from Lamiaceae family, used traditionally in the treatment of cognitive disorders. It has cholinomimetic ...

background melissa officinalis, an herbal drug, is well known and frequently applied in traditional and modern medicine. yet, there is inadequate information regarding its effects on electrical properties of the heart. the present study attempted to elucidate the effects of melissa officinalis aqueous extract on electrocardiogram (ecg) in rat. objectives ecg is an easy, fast and valuable tool t...

State -dependent learning is the phenomenon through which memory retrieval is most efficient when an individual is in the same state of consciousness as they were when the memory was formed. M. officinalis has also terpenoides that is useful in memory and learning. Moreover nicotine can affect on memory and learning by nicotinic receptors of hippocampus cholinergic system. The present study was...

OBJECTIVE We aimed to assess the influence of Melissa officinalis (lemon balm), a well-known herbal drug with numerous applications in traditional and modern medicine, on cardiac conduction and susceptibility to lethal ventricular arrhythmia. MATERIALS AND METHODS Forty-two male Wistar rats were divided into a control group (CTL), an M. officinalis group that received the aqueous extract of M...