background: malignant melanoma is a highly aggressive malignant melanocytic neoplasm which resists against the most conventional therapies. sea cucumber as one of marine organisms contains bioactive compounds such as polysaccharide, terpenoid and other metabolites which have anti-cancer, anti-tumor, anti-inflammatory and antioxidant properties. the present study was designed to investigate the ...

Background & Objective: This study was designed for the first time for the detection of mutant BRAF V600E and its correlation with clinicophathologic features in a sample of Iranian patients with pathologically proved pigmented skin neoplasms.Methods: 82 paraffin-embedded blocks, including melanocytic nevi, malignant melanoma, Basel cell carcinoma, and sq...

Background: Skin cancer is one of the most common forms of cancer in the world and melanoma is the deadliest type of skin cancer. Both melanoma and melanocytic nevi begin in melanocytes (cells that produce melanin). However, melanocytic nevi are benign whereas melanoma is malignant. This work proposes a deep learning model for classification of these two lesions.    Methods: In this analytic s...

background: malignant melanoma is a highly metastatic cutaneous cancer and typically refractory to chemotherapy. deregulated apoptosis has been identified as a major cause of cancer drug resistance, and upregulated expression of the inhibitor of apoptosis protein melanom, an inhibitor of apoptosis (ml-iap) is frequent in melanoma. methods: based on the conclusion that ml-iap expression contribu...

skin cancer has a broad and burdensome impact on the health and well-being of iranian and account for substantial health care costs to the nation. the first most common form of skin cancer is basal cell carcinoma (bcc); followed by the squamous cell carcinoma (scc) and the incidence of malignant melanoma (mm) is lower but is fatal. kaposi sarcoma (ks) is a tumor caused by human herpes virus 8. ...

Skin cancer is usually classified as melanoma and non-melanoma. Melanoma now represents 75% of humans passing away worldwide one the most brutal types cancer. Previously, studies were not mainly focused on feature extraction Melanoma, which caused classification accuracy. However, in this work, Histograms orientation gradients local binary patterns procedures are used to extract important featu...

Abstract Melanoma is one of the most aggressive and lethal skin cancers. Lucidadiol a triterpenoid isolated from Ganoderma lucidum known to have various biological functions, including antibacterial effects. However, anti-cancer effects mechanism action lucidadiol in malignant melanoma are unknown. In this study, significantly reduced B16 cell viability dose- time-dependent manner. addition, in...

Abstract Melanoma is the most dangerous type of cancer, with a high rate metastasis. The conventional method treating skin melanoma photodynamic therapy, yet this phototherapy has several side effects. In addition, photosensitizers used are relatively expensive and toxic. Thus, developing methods cancer using laser only promising area research. Here we present in vitro effects cell culture afte...

People with skin of color are more likely to have advanced melanomas at diagnosis, strikingly lower 5-year melanoma survival rates among Black (70%) compared white patients (92%). Yet, survey data suggests many people not been provided health information about cancer. We sought explore people’s perspectives on risk using in-depth qualitative interviewing. conducted 26 semi-structured interviews...