Among many oncological patients we can notice a substantial loss of body weight, fat and proteins with significant proinflammatory activity at the time of diagnosis. This wasting condition is well known as cancer cachexia syndrome. Anorexia is important part of this syndrome. Because cancer cachexia reduces tumor response to treatment and it is an indicator of poor prognosis, we need to start c...

BACKGROUND The effectiveness of drugs aimed at counteracting cancer cachexia is generally tested in pre-clinical rodent models, where only the tumour-induced alterations are taken into account, excluding the co-presence of anti-tumour molecules that could worsen the scenario and/or interfere with the treatment. METHODS The aim of the present investigation has been to assess the efficacy of a ...

A rising concern among clinicians is treatment of unplanned weight loss in the elderly, especially given the predicted growth of this population over the next few decades. Unexpected weight loss in the geriatric patient worsens overall health outcomes. A variety of pharmacotherapeutic options are available for treatment; however, evidence underlying their use is limited, and none has gained app...

in this work attempts were made to evaluate k+-sds and hydrocolloid polymer-sds interactions in flocculation of megestrol acetate dispersions to enhancetheir stability as a part of suspension formulation. different dispersions of micronized megestrol acetate and sds were prepared. kcl and kh2po4 and their corresponding sodium salts were added to the dispersions and the preparations were evaluat...

Malnutrition is a common clinical problem in dialysis patients. So far the management of malnutrition in this population has not been fully successful. The aim of the study was to evaluate the efficacy and safety of use of megestrol acetate suspension in malnourished dialysis patients. Twenty-six hypoalbuminemic (albumin < or = 3.8 g/dl) dialysis patients took 160 mg of megestrol acetate daily ...

Myoclonus is a clinical sign characterized by brief, involuntary, jerky contraction or lapse of muscle group muscles, which can be associated with cerebral disorders, epileptic and drugs. Megestrol acetate (MGA) synthetic derivative progestin, has been widely used in practice for increasing appetite patients severe anorexia malignancies. We experienced 68-year-old female patient who myoclonus a...