A medullary thyroid carcinoma is a malignant tumor derived from the C-cells of the thyroid. Despite their distinct embryological origin, medullary thyroid carcinomas are exceptionally accompanied by a tumor derived from the follicular cells; this is defined as mixed medullary and follicular cell carcinoma. There have been controversies regarding the origin of this rare mixed thyroid carcinoma q...

Medical records of 228 patients who had undergone thyroid surgery were studied. There were 179 females and 49 males with mean age of 33-8 years. Pre-op. diagnosis was cold nodule in 4. 4 %. Pathology diagnosis was simple goiter in 54%, adenoma in 23%, thyroid cancer in 15% and colloid cyst in 5.3% of the patients. Among carcinomas 68% were papillary, 29% follicular and 3% medullary. There were1...

MEN (multiple endocrine neoplasia) type 2 syndrome is an inherited disease characterized by medullary thyroid carcinoma, pheochromocytoma, hyperparathyroidism and/or developmental anomalies. Germ-line mutations of the RET proto-oncogene have recently been identified as the underlying cause of the syndrome. Accordingly, several investigators have advocated prophylactic total thyroidectomy for me...

BACKGROUND In 2015, thyroid carcinoma affected approximately 63,000 people in the USA, yet it remains one of the most treatable cancers. It is mainly classified into medullary and non-medullary types. Conventionally, medullary carcinoma was associated with heritability but increasing reports have now begun to associate non-medullary thyroid carcinoma with a genetic predisposition as well. It is...

Recent reports have demonstrated that long-term and high dosage treatments with incretin-based medicine, such as hormone glucagon-like peptide-1 (GLP-1) may induce thyroid C-cell pathological changes in rodents, rather than in humans. Doubts regarding the tumorigenic potential of GLP-1 analogues in human thyroid C-cells remain. The present study aimed to determine the expression levels of GLP-1...

twenty-one patients with medullary thyroid carcinoma were studied prospectively with tc-99m (v) dmsa after surgery. pentavalent dmsa scintigram demonstrated abnormal uptake in 13 and equivocal uptake in 6 patients. finally, seven patients with surgical or other imaging documentation were selected for this paper. most of these patients were asymptomatic. six patients had hypercalcitonemia and se...

INTRODUCTION Medullary thyroid carcinoma may occur in a sporadic (s-medullary thyroid carcinoma, 75%) or in a multiple endocrine neoplasia type 2 form (MEN2, 25%). These clinical forms differ in many ways, as s-medullary thyroid carcinoma cases are RET-negative in the germline and are typically diagnosed later than medullary thyroid carcinoma in MEN2 patients. In this study, a set of cases with...