Extracts of Desmodium adscendens (Sw) DC are used for the treatment of various diseases but limited toxicological evaluations have been done on the medicinal plant. This study investigates toxicity effects of the leave extract of D adscendens, and the possibility of drug-drug interaction of the plant extract when co-administered with other drugs. Oral administrations of leaf extract of D adscen...

A wide range of parts of the medicinal plant is used for extract as raw drugs and they possess varied medicinal properties. The different parts are used include root, stem, flower, fruit, twigs exudates and modified plant organs. One of the greatest accomplishments of modern medicine has been the development of antimicrobials for the treatment of infectious diseases. Microbial diseases remain a...

At the early drug discovery stage, the high-throughput parallel artificial membrane permeability assay is one of the most frequently used in vitro models to predict transcellular passive absorption. While thousands of new chemical entities have been screened with the parallel artificial membrane permeability assay, in general, permeation properties of natural products have been scarcely evaluat...

Azadirachta indica is a very useful traditional medicinal plant in the sub-continent and each part of the tree has some medicinal properties. The plant is native to Asia, but has now naturalized in West Africa and is widely cultivated in Nigeria as an ornamental as well as medicinal plant. Fresh leaves of the plant were collected, dried, homogenized and extracted using 95% Ethanol, Methanol and...

Pharmaceutical industries are still in the hunt of effective scavengers for free radicals from the unexplored medicinal plants. About 80,000 species of plants are utilized for treating various diseases in different systems of Indian medicine. Many pharmaceutical companies giving importance in plant-derived drugs mainly due to the current widespread belief that 'Green Medicine' is safe and more ...

PURPOSE The antiviral activity of Indian Medicinal plant extract Swertia chirata was tested against Herpes simplex virus (HSV) type-1, using multiple approaches both at cellular and molecular level. METHODS Cytotoxicity, plaque reduction, virus infectivity, antigen expression and polymerase chain reaction (PCR) assays were conducted to test the antiviral activity of the plant extract. RESUL...

Garcinia lanceifolia Roxb. is an important and endemic medicinal plant of Assam which has been used by various ethnic communities of Northeast India to treat various disorders like dysentery, dyspepsia, and biliousness. The plant is considered to be containing much medicinal value and is also eaten raw or made into pickles by the local people. Our present study has been focused on the evaluatio...

The in vitro antimicrobial activity of the crude methanolic and ethanolic leaf extract of Bridelia retusa (L.) Spreng. was studied against four gram negative and two gram positive bacteria. The results showed that both the extracts showed antimicrobial activity. Maximum zone of inhibition was observed in the methanolic extract against Escherichia coli which was 29.5 ± 0.50. However, ethanolic e...

Studies on the antibacterial activities of the leaf extract of Citrullus colocynthis (Cucurbitaceae), a medicinal plant used for the treatment of various ailments was carried out using agar disc diffusion technique. The results revealed that the crude acetone extract exhibited antibacterial activities against Pseudomonas aeruginosa with zones of inhibition measuring 14.0mm. The chloroform leaf ...

An extract of an unidentified green filamentous fungus isolated as an endophyte of the Canadian medicinal plant Geum macrophyllum exhibited significant antimycobacterial activity and a distinct 1H NMR profile. Bioassay guided fractionation indicated that the natural product phomopsolide A (1) was responsible for the distinguishing characteristics of the extract.