This paper deals with PICSEL mediator systems which integrate services. We propose a scalable approach which exploits standardized specifications provided by normalization organisms. The paper focuses on the use of such specifications to automate the construction of the mediator. An illustration in the tourism domain with OTA specifications is given.

Wnt target gene transcription is mediated by nuclear translocation of stabilized beta-catenin, which binds to TCF and recruits Pygopus, a cofactor with an unknown mechanism of action. The mediator complex is essential for the transcription of RNA polymerase II-dependent genes; it associates with an accessory subcomplex consisting of the Med12, Med13, Cdk8, and Cyclin C subunits. We show here th...

The conserved protein complex known as Mediator conveys transcriptional signals by acting as an intermediary between transcription factors and RNA polymerase II. As a result, Mediator subunits play multiple roles in regulating developmental as well as abiotic and biotic stress pathways. In this report we identify the head domain subunits MEDIATOR18 and MEDIATOR20 as important susceptibility fac...

The Mediator EnvirOnment for Multiple Information Sources (MOMIS) aims at constructing synthesized, integrated descriptions of the information coming from multiple heterogeneous sources, in order to provide the user with a global virtual view of the sources independent from their location and the level of heterogeneity of their data. Such a global virtual view is a conceptualization of the unde...

Many clinical domains involve the collection of different types and substantial numbers of data over time. This is especially true when monitoring chronic patients. It is highly desirable to assist human users (e.g., clinicians, researchers), or decision support applications (e.g., diagnosis, therapy, quality assessment), who need to interpret large amounts of time-oriented data by providing a ...

A mediator is a domain-speciic tool to support uniform access to multiple heterogeneous information sources and to abstract and combine data from different but related databases to gain new information. This middleware product is urgently needed for these frequently occurring tasks in a decision support environment. In order to provide a front end, a mediator usually deenes a new language. If a...

Surfactant proteins A and D (SP-A and SP-D) are lung collectins composed of two regions, a globular head domain that binds PAMPs and a collagenous tail domain that initiates phagocytosis. We provide evidence that SP-A and SP-D act in a dual manner, to enhance or suppress inflammatory mediator production depending on binding orientation. SP-A and SP-D bind SIRPalpha through their globular heads ...

A critical problem in building an information mediator is how to translate a domain-level queries into an e cient query plan for accessing the required data. We have built a exible and e cient information mediator, called SIMS. SIMS takes a domain-level query and dynamically selects the appropriate information sources based on their content and availability, generates a query access plan that s...

PEA3, ERM and ER81 belong to the PEA3 subfamily of Ets transcription factors and play important roles in a number of tissue-specific processes. Transcriptional activation by PEA3 subfamily factors requires their characteristic amino-terminal acidic transactivation domain (TAD). However, the cellular targets of this domain remain largely unknown. Using ERM as a prototype, we show that the minima...

A critical problem in building an information mediator is how to translate a domain-level query into an efficient query plan for accessing the required data. We have built a flexible and efficient information mediator, called SIMS. This system takes a domain-level query and dynamically selects the appropriate information sources based on their content and availability, generates a query access ...