The culture media optimization is an inevitable part of upstream process development in therapeutic monoclonal antibodies (mAbs) production. The quality by design (QbD) approach defines the assured quality of the final product through the development stage. An important step in QbD is determination of the main quality attributes. During the media optimization, some of the main quality attribute...

Today more and more media data is produced completely in the digital domain without the need of analogue input. This brings an increase of flexibility and efficiency in media handling, as distributed access, duplication and modification are possible without the need to move or touch physical data carriers. But this also reduces the security of the process: Without physical originals to refer to...

It is evident that there are numerous interacting factors which affect streptolysin in the presence of fermented sugars. The principal action is the change in the metabolism of the streptococcus by which more carbohydrate and less protein is utilized; although the growth is much increased there is proportionately less hemolysin. The acid developed in these cultures not only lessens the vitality...

Contemporary scientific media production requires a complex socio-technical infrastructure we call the "Media Production Pipeline" (MPP). Media professionals engage with researchers along the MPP to disseminate science news to the lay public. However, differing incentive structures and professional contexts frequently set researchers’ values and needs at odds with those of media professionals, ...

In this study, urease production was investigated among thirteen strains of Aspergillus niger seven strains isolated from soils of Semnan province in Iran and six strains obtained from Persian Type Culture Collection (PTCC). The enzyme production was screened in two submerged media quantitatively. The registered PTCC 5011 and the native S31 strains showed more urease production than the other e...

Three media formulated from molasses and cornsteep liquor and another media based on the basal medium formulation of IPS-82 were assessed for the growth and production of insecticidal properties of B. thuringiensis H-14 .• Bacterial powders prepared from the broth cultures were assayed against the larvae of Culex pipiens and Anopheles stephensi. A standard powder of IPS-82 was included in ...

different compositions of liquid media were used for their efficacy in the production of beta-galactosidase by aspergillus oryzae in submerged fermentation. enzyme production was improved by switching from lactose-based media to soybean meal- and wheat bran-based media. further improvement was made when the soybean meal medium was supplemented with sodium nitrate and magnesium sulfate. results ...