Covalent polymer mechanochemistry offers promising opportunities for the control and engineering of reactivity. To date, covalent mechanochemistry has largely been limited to individual reactions, but it also presents potential for intricate reaction systems and feedback loops. Here we report a molecular architecture, in which a cyclobutane mechanophore functions as a gate to regulate the activ...

A detailed investigation into the mechanochemical synthesis of coordination pillared-layer frameworks (CPLs), particularly CPL-1, was carried out. In the case of CPL-1, a two-step reaction was observed (from the starting reactants to the final product). In the conventional solution process, no intermediate state was detected. We found that moisture is essential in both the reaction steps. After...

Mechanochemistry makes the next move in advancing organometallic synthesis. In their Research Article (e202305775), Riina Aav, Dzmitry G. Kananovich et al. report a mechanochemical adaptation of Mg-mediated Barbier reaction, which overcomes limitations classic solvent-based approach. Mechanochemical activation enables rapid generation Grignard reagents situ, making process resistant to air and ...

Boc protection group could be readily removed in a very mild mechanochemical conditions. In a short reaction time, ball milling of Boc-protected amines with p-toluenesulfonic acid in solvent-free conditions affords corresponding amine p-TsOH salts.

Lithiated polysilane was synthesized by the mechanochemical reaction of layered polysilane with metallic lithium. The resulting dark green powder formed a Si-Li bond on the surface and demonstrated electroconductivity.

Mechanochemical coupling was studied for myosin II and V consistently. The fluctuation in myosin V motility was determined by correlating the stochasticity of the ATPase reaction with regular displacements per one ATP, consistent with a tight mechanochemical coupling. In contrast, myosin II, working in an ensemble, was explained by a loose coupling, generating variable step sizes which depend o...

synthetic hydroxyapatite (ha) is the most helpful because of its similarity to natural bone in both crystalline structure and chemical composition. recently, fluoridated hydroxyapatite (fha) has been developed in dental and orthopedic application because it has lower solubility than pure ha, while maintaining the comparable bioactivity and biocompatibility. the aim of this study was to synthesi...