In the past years, a number cardiac electromechanics models have been developed to better understand the excitation-contraction behavior of the heart. However, there is no agreement on whether inertial forces play a role in this system. In this study, we assess the influence of mass in electromechanical simulations, using a fully coupled finite element model. We include the effect of mechano-el...

From accumulating studies of hexameric helicases, a mechano-chemical coupling mechanism has emerged which postulates that the nucleoside triphosphate (NTP) hydrolysis is sequentially coordinated together with the binding and translocation of nucleic acid substrate. Various mechano-chemical models have been proposed for different hexameric helicases with no consensus for a common mechanism. To e...

The arterial baroreflex system may be divided into the mechano-neural arc from pressure input to sympathetic nerve activity (SNA) and the neuro-mechanical arc from SNA to arterial pressure (AP). We explored a new strategy to estimate total baroreflex gain (Gbaro) using an equilibrium diagram between the mechano-neural and neuromechanical arcs. In 8 anesthetized rabbits, a neck suction procedure...

In brief: Chondrocyte-specific ablation of the mechano-sensory Piezo1 results in substantially impaired formation secondary spongiosa during endochondral bone formation. The study explores this unexpected finding and show that mechano-sensing growth plate chondrocytes directly regulates trabeculae spongiosa.

Crayfish (A. astacus) stretch receptors are an example of invertebrate muscle stretch receptors. They show strong homology to mammalian muscle spindles and bi-polar neurons in D. melanogaster, which are typical, non-ciliated, multi-dendritic, afferent neurons. Such receptors are observed in many species and perform an important sensory role. However, they are poorly characterised. A previous bi...

In the fern Adiantum capillus-veneris, chloroplast movement is induced by mechanical stimulation as well as by light stimulation. Directional movement of both types depends on an actin-based motile system. To investigate the physiological relationship between mechanical and light signaling in the regulation of chloroplast movement, we examined the mechanoresponse of chloroplasts whose motility ...

nanoparticles of manganese-dioxide synthesized by mechano-chemical reaction were used foras(iii) and as(v) sorption from water environment. the influence of a milling time of manganese-dioxide on sorption was examined with batch procedure. sorption as a function of contact time was investigated. kinetic of sorption, for both as(iii) and as(v), was fast. the equilibrium condition for milled sorb...