INTRODUCTION Nano-indentation has recently been employed as a powerful tool for determining the mechanical properties of biological tissues on nano and micro scales. A majority of soft biological tissues such as ligaments and tendons exhibit viscoelastic or time-dependent behaviors. The constitutive characterization of soft tissues is among very important subjects in clinical medicine and espec...

Periodontal diseases are highly prevalent inflammatory diseases that lead to a destruction of tooth-supporting tissues, such as the periodontal ligament, alveolar bone and cementum, and ultimately result in tooth loss. Conventional treatment for periodontal diseases is the mechanical removal of the periodontal biofilm, which although effective in reducing inflammation in lesion sites, dose not ...

Mechanical force was shown to promote IGF-1 expression in periodontal ligament both in vitro and in vivo. Though the mechanism of this effect has not yet been proved, here we investigated the molecular mechanism of intermittent mechanical stress on IGF-1 expression. In addition, the role of hypoxia on the intermittent compressive stress on IGF-1 expression was also examined. In this study, huma...

avulsion is one of the most serious emergencies in dental office. in the event of any problem, the tooth should be stored in a medium that supports the periodontal ligament cell viability. in other clinical situations, preserving media, growth factors and mitogenic products may be useful in repairing the traumatized tissues. it has been previously reported that levodopa (l-dopa) accelerates hea...

background: periodontal ligament stem cells (pdlscs) are considered as a type of mesenchymal stem cell that is beneficial target for numerous clinical applications in periodontal tissue regeneration therapy. materials and methods: this study examined the effects of dexamethasone (dex) on human pdlscs in vitro. pdlscs obtained from the roots of patient’s teeth were cultured with dex (0.01 μm), a...

Both periodontal ligament and gingival tissue are thought to harbor cells with the ability to stimulate periodontal regeneration, i.e., formation of new bone, cementum, and connective tissue attachment. To understand further the role of these cells in the regenerative process, we compared human periodontal ligament cells and gingival fibroblasts, both derived from the same patient, same passage...

INTRODUCTION As one group of periodontal ligament (PDL) cells, human periodontal ligament stem cells (hPDLSCs) have been isolated and identified as mesenchymal adult stem cells (MSCs) since 2004. It has been well accepted that PDL sensitively mediates the transmission of stress stimuli to the alveolar bone for periodontal tissue remolding. Besides, the direction of MSCs differentiation has been...

The biological principle of GTR is based on experimental studies demonstrating that the progenitor cells capable of forming new cementum with inserting collagen fibers (i.e. new connective tissue attachment) have their source in the periodontal ligament. By placing a mechanical barrier to cover the periodontal defects, the downgrowth of the epithelial cells can be stopped and the stability of t...

PURPOSE The aim of this article is to review a group of lesions associated with periodontal ligament (PDL) widening. MATERIALS AND METHODS An electronic search was performed using specialized databases such as Google Scholar, PubMed, PubMed Central, Science Direct, and Scopus to find relevant studies by using keywords such as "periodontium", "periodontal ligament", "periodontal ligament space...

Orthodontic forces are capable of reorganizing and remodeling the periodontal ligament, to facilitate tooth movement. Optimal forces will produce favorable tissue responses, but whenever this balance is lost (as in the case of high force magnitudes, or in the presence of reduced periodontal support), the periodontal ligament may respond differently. This review highlights the responses of the p...