نتایج جستجو برای: meca protein

تعداد نتایج: 1236161  

Journal: :The Journal of antimicrobial chemotherapy 1999
T M Weller

The presence and sequences of genes that regulate the expression of methicillin resistance was investigated in 42 isolates of Staphylococcus aureus and 102 isolates of coagulase-negative staphylococci (CNS). PCR was used to detect mecA and the regulatory genes mecR1 and mecI. In a selected group of isolates, the sequences of mecI and the mec promoter region were also determined and compared wit...

Journal: :Polish journal of veterinary sciences 2013
M Bochniarz W Wawron M Szczubial

The aim of this study was to determine the mechanisms of staphylococcal resistance to methicillin. CNS (n = 100 isolates) were prepared from the mammary inflammatory secretions of 86 cows from farms located in the Lublin region. Methicillin-resistant isolates constituted 20.0% of all CNS. Staphylococcus sciuri (n=8) and Staphylococcus xylosus (n=6) were most abundant, followed by Staphylococcus...

2014
Tianhua Ren Yumei Qiu Weiyun Wu Xiao Feng Shicai Ye Zhuang Wang Ting Tian Yanting He Caiyuan Yu Yu Zhou

To investigate the expression of adenosine A3 receptor (A3AR) in human colonic epithelial cells and the effects of A3AR activation on tumor necrosis factor alpha (TNF-α-) induced inflammation in order to determine its mechanism of action in human colonic epithelial cells, human colonic epithelial cells (HT-29 cells) were treated with different concentrations of 2-Cl-IB-MECA prior to TNF-α stimu...

Journal: :Japanese journal of ophthalmology 1998
H Tsuji T Tsuru K Okuzumi

To examine contamination of donor eye preservation media with methicillin-resistant Staphylococcus aureus (MRSA), we studied the media to detect specific genes for MRSA by use of the polymerase chain reaction (PCR) method. The materials were 36 samples of donor eye preservation media (EP-II) in which donor eyes had been stored for keratoplasty. Polymerase chain reaction procedures were carried ...

2011
Duarte C. Oliveira Hermínia de Lencastre

Methicillin-resistant Staphylococcus aureus (MRSA) is intrinsically cross-resistant to virtually all β-lactam antibiotics. The central determinant for the MRSA phenotype is the mecA gene, whose transcriptional control may be mediated by a repressor (mecI) and a sensor/inducer (mecR1). The mecI-mecR1-mediated induction of mecA takes several hours rendering the strains phenotypically susceptible ...

Journal: :Alcohol and alcoholism 2011
Oluwatosin A Adaramoye Adekunbi Aluko

AIMS The present work studied the modulatory role of methanolic extract of Cnidoscolus aconitifolius leaf (MECA) in rat model of renal dysfunction induced by chronic ethanol administration. METHODS Forty-two male Wistar albino rats weighing between 170 and 180 g were distributed into seven groups of six animals each. Some groups were pretreated with MECA (100 and 200 mg/kg) or kolaviron (KV) ...

Journal: :Journal of clinical microbiology 2016
M T Wu C-A D Burnham L F Westblade J Dien Bard S D Lawhon M A Wallace T Stanley E Burd J Hindler R M Humphries

Staphylococcus pseudintermedius is a coagulase-positive species that colonizes the nares and anal mucosa of healthy dogs and cats. Human infections with S. pseudintermedius range in severity from bite wounds and rhinosinusitis to endocarditis; historically, these infections were thought to be uncommon, but new laboratory methods suggest that their true incidence is underreported. Oxacillin and ...

Journal: :Proceedings of the National Academy of Sciences 2003

Journal: :Journal of bacteriology 2001
T K McKinney V K Sharma W A Craig G L Archer

Resistance to beta-lactam antibiotics in staphylococci is mediated by mecA and blaZ, genes encoding a penicillin-binding protein (PBP2a) with low beta-lactam affinity and beta-lactamase, respectively. The mec and bla regulators, mecR1-mecI and blaR1-blaI, respectively, encode inducer-repressors with sufficient amino acid homology to suggest that they could coregulate PBP2a production. In order ...

Journal: :The EMBO journal 1998
K Turgay J Hahn J Burghoorn D Dubnau

Competence is a physiological state, distinct from sporulation and vegetative growth, that enables cells to bind and internalize transforming DNA. The transcriptional regulator ComK drives the development of competence in Bacillus subtilis. ComK is directly required for its own transcription as well as for the transcription of the genes that encode DNA transport proteins. When ComK is sequester...

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