High-performance computing (HPC) has become a state strategic technology in a number of countries. One hypothesis is that HPC can accelerate biopharmaceutical innovation. Our experimental data demonstrate that HPC can significantly accelerate biopharmaceutical innovation by employing molecular dynamics-based virtual screening (MDVS). Without using HPC, MDVS for a 10K compound library with tens ...

Abstract In the Ross Sea sector of Antarctica, periodic large-scale marine ice-sheet fluctuations since mid-Miocene are recorded by drill core and seismic data, revealing a dynamic response to past increases in temperature atmospheric CO2. adjacent, predominantly ice-free McMurdo Dry Valleys (MDVs), preserved terrestrial landscapes reflect persistent cold conditions have been interpreted as ind...

Available soil moisture is thought to be the limiting factor for most ecosystem processes in cold polar desert of McMurdo Dry Valleys (MDVs) Antarctica. Previous studies have shown that microfauna throughout MDVs are capable biological activity when sufficient available (~2–10% gravimetric water content), but few attempted quantify distribution, abundance, and frequency on scales beyond traditi...

This paper extends the current concept of multiple description coding (MDC) to our proposed domain, by proposing efficient splitting of standard single description coded (SDC) video into a multi-stream representation. The multiple description video splitting (MDVS) scheme is proposed to operate at network edge, which increase robustness in path diversity video streaming across heterogeneous com...

Damaged mitochondrial content is packaged in mitochondrial-derived vesicles (MDVs), which are targeted for degradation through an unclear mechanism. McLelland et al. (2016. J. Cell Biol. http://dx.doi.org/10.1083/jcb.201603105) show that the SNARE Syntaxin-17 mediates MDV fusion with endolysosomes, promoting the delivery of mitochondrial cargo to lysosomes for degradation.

Mitochondria accumulate damage over time, which can lead to impairment of cell function by excessive production of reactive oxygen species. The PINK1/Parkin pathway therefore monitors the quality of the mitochondrial population and stimulates the elimination of depolarized organelles by mitophagy. In this issue of The EMBO Journal, McLelland et al (2014) show that this pathway also responds to ...

We previously reported that mosquito densoviruses (MDVs) are potential vectors for delivering foreign nucleic acids into mosquito cells. However, considering existing expression strategies, recombinant viruses would inevitably become replication-defective viruses and lose their ability for secondary transmission. The packaging limitations of the virion represent a barrier for the development of...

Recently, space time block codes (STBCs) are proposed for multi-input and multi-output (MIMO) antenna systems. Designing an STBC with both low decoding complexity and non-vanishing property for the Long Term Evolution Advanced (LTE-A) remains an open issue. In this paper, first our previously proposed STBC’s non-vanishing property will be completely described. The proposed STBC scheme has some ...

Hierarchical identity-based broadcast encryption (HIBBE) organizes the users in a tree-like structure in which they can delegate the decryption ability to their subordinates. In addition, the trusted third party (TTP) can reduce its burden because the users’ secret keys can be generated in a distributed mechanism by users’ supervisors. HIBBE enables encrypting a message for any arbitrary set of...