This paper reviews the principle of Minimum Description Length (MDL) for problems of model selection. By viewing statistical modeling as a means of generating descriptions of observed data, the MDL framework discriminates between competing models based on the complexity of each description. This approach began with Kolmogorov's theory of algorithmic complexity, matured in the literature on info...

In multimode fiber transmission systems, mode-dependent loss and gain (collectively referred to as MDL) pose fundamental performance limitations. In the regime of strong mode coupling, the statistics of MDL (expressed in decibels or log power gain units) can be described by the eigenvalue distribution of zero-trace Gaussian unitary ensemble in the small-MDL region that is expected to be of inte...

The current study assessed the validity and reliability of a miniaturised data logger (MDL) against a radio-frequency-based indoor tracking system (ITS) for quantifying key aspects of mobility performance during wheelchair rugby. Eleven international wheelchair rugby players were monitored by both devices during four wheelchair rugby matches. MDL data were averaged over both 1-second (MDL-1) an...

BACKGROUND/AIMS The polyamine oxidase inhibitor MDL-72527 (N1,N4-bis(2,3-butadienyl)-1,4-butanediamine) were expected to increase the abundance of spermine, a powerful inhibitor of platelet activation. Nothing is known, however, on the sensitivity of platelet function and survival to MDL-72527 exposure. The present study thus explored whether MDL-72527 modifies function and survival of platelet...

In this paper, we present the implementation of a novel domain-specific language (DSL) for pharmacometric modeling called the Modelling Description Language (MDL). MDL is a modular, declarative language with block structures that allows users to abstract data, processes and mathematical models from auxiliary code, and hence, improves model readability, reusability and opportunities for collabor...

The Angiotensin I converting enzyme (ACE, EC 3.4.14.1, kininase II) and neutral endopeptidases (NEP, NEP 24.11) are mechanistically related metallopeptidases. They play a key role in the regulation of blood pressure, body fluid homeostasis and cell growth. Therefore, they are implicated in the pathogenesis of arterial hypertension, congestive heart failure, left ventricular remodeling after myo...

Rissanen's Minimum Description Length (MDL) principle is a statistical modeling principle motivated by coding theory. For exponential families we obtain pathwise expansions, to the constant order, of the predictive and mixture code lengths used in MDL. The results are useful for understanding diierent MDL forms.

MDL 62,879 (formerly GE 2270 A) is a novel antibiotic active against Gram-positive bacteria by inhibiting protein synthesis. MDL 62,879 is not active against Gram-negative bacteria, but inhibits cell-free protein synthesis in extracts from Escherichia coli, and shows a high binding affinity for its elongation factor Tu (EF-Tu). We prepared ribosomes and protein-synthesis elongation factors from...

The paper deals with the task of polynomial regression, i.e., inducing polynomial that can be used to predict a chosen dependent variable based on the values of independent ones. As in other induction tasks, there is a trade-off between the complexity of the induced polynomial and its predictive error. One of the approaches for searching an optimal trade-off is the Minimal Description Length pr...

(2R,5R)-6-Heptyne-2,5-diamine hydrochloride (MDL 72175) is a new, potent, and selective inhibitor of mammalian ornithine decarboxylase. MDL 72175 given p.o. in drinking fluid reduced by 80% the growth of EMT6 sarcoma in mice and of HTC hepatoma in rats. It prolonged the survival of mice bearing L1210 or P388 leukemias and inhibited the development of Lewis lung carcinoma in mice at doses 10- to...