نتایج جستجو برای: mdk
تعداد نتایج: 338 فیلتر نتایج به سال:
Midkine (MDK) and Pleiotrophin (PTN) are small heparin-binding cytokines with closely related structures. The Drosophila genome harbours two genes encoding members of the MDK/PTN family of proteins, known as miple1 and miple2. We have investigated the role of Miple proteins in vivo, in particular with regard to their proposed role as ligands for the Alk receptor tyrosine kinase (RTK). Here we s...
INTRODUCTION Hepatocellular Carcinoma (HCC) is a primary tumor of the liver; it is one of the most common cancers worldwide. Osteopontin (OPN) is a phosphorylated glycoprotein which is implicated in enhancing invasive and metastatic progression of many tumors. Midkine (MDK) is a 13-kDa small heparin-binding growth factor which plays a significant role in carcinogenesis related activities. The a...
Cellular senescence is a state of irreversible growth arrest that can be triggered by multiple mechanisms, including telomere shortening, the epigenetic derepression of the INK4α/ARF locus and DNA damage. Senescence has been considered a tumor‑suppressing mechanism that permanently arrests cells at risk for malignant transformation. However, accumulating evidence shows that senescent cells have...
The cephalosporins are a family of semisynthetic antibiotics, some of which have structural features associated with substrates for the multidrug transporter, P-glycoprotein. The activity of a series of six cephalosporins in reversing multidrug resistance (MDK) was examined in MDK variants (Do cells) of the human sarcoma line MES-SA. DxS cells express high levels of the mdr\ gene product P-glyc...
An increasing number of cadaveric kidney transplants are now performed with organs from donors who would have been deemed unsuitable in earlier times. Although good allograft outcomes have been obtained with these marginal donor transplants, it is unclear whether recipients of marginal kidney transplants achieve a reduction in long-term mortality as do recipients of "ideal" kidneys. Patients wi...
This study aims to analyze the implementation of Corporate Social Responsibility (CSR) conducted by PT. Multi Dimensi Kreasi (MDK) in fish farming empowerment program Bokesan Village, Sindumartani Sleman, Yogyakarta. The research method is qualitative. sampling technique used was purposive sampling, snow ball and Forum Group Discussion (FGD). Data collection techniques: interviews, observation,...
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