Mucin depleted foci (MDF) are precancerous lesions of the colon in carcinogen-treated rodents and humans at high risk. Since MDF show signs of inflammation we hypothesized that the defective mucous production would expose them to the risk of being penetrated by intestinal bacteria, which can be sensed by Toll-like receptors (Tlrs) and activate inflammatory pathways. To verify this hypothesis we...

An improved mass defect filter (MDF) method employing both drug and core structure filter templates was applied to the processing of high resolution liquid chromatography/mass spectrometry (LC/MS) data for the detection and structural characterization of oxidative metabolites with mass defects similar to or significantly different from those of the parent drugs. The effectiveness of this approa...

The potential use of nanoclay was examined to modify fluid transfer properties of medium density fiberboard (MDF). For this, Na+ montmorillonite (Na+MMT) nanoclay was added to urea formaldehyde resin to produce MDF. Then, the air permeability and mass diffusivity of MDF were evaluated. Scanning electron microscope (SEM) images and X-ray diffraction (XRD) confirmed a dispersion and exfoliation o...

BACKGROUND Flat aberrant crypt foci (flat ACF) and mucin-depleted foci (MDF) are preneoplastic lesions identified in the colon of carcinogen-treated rodents stained with methylene blue (MB) and high iron diamine-alcian blue (HID-AB), respectively. The correspondence between flat ACF and MDF in the same colon of Min mice treated with azoxymethane (AOM) and of F344 rats treated with 1,2-dimethylh...

AIMS We evaluated the effect of modified Davidson's fixative (mDF) on the number of lymph nodes examined and staging in patients with colon carcinoma. METHODS The results of two different fixation methods used in the pathological preparation of the resection specimens were analyzed. A traditional formalin preparation with manual dissection of all nodes was performed in 117 colon specimens bet...

The objective of this study was to determine the effects of some boron compounds, which have fire retardant properties, as well as melamineurea-formaldehyde (MUF) resins having different melamine contents (10%, 15%, and 20%) on some physical and mechanical properties of medium density fiberboard (MDF) panels. It was found that the water absorption (WA) and thickness swelling (TS) of MDF panels ...

Massive Data Flow (MDF) is everywhere these days; from data about neural cells, social insects and genetic networks, to Lifelog (digital storage of a person’s visual and audio life log) and SNS (Social network service) data streams. Current web and device technology has made it possible for us to record detailed and massive data flows of artificial and real living systems. But how can we analyz...

We have used Hubble Space Telescope Wide Field Planetary Camera 2 observations to construct a color-magnitude diagram (CMD) for the bulge of M31 at a location ∼1.6 kpc from the galaxy’s center. Using scaled-solar abundance theoretical red giant branches with a range of metallicities, we have translated the observed colors of the stars in the CMD to abundances and constructed a metallicity distr...

The paper presents a unitary approach of the use of a Molecular Descriptors Family in structure-property/activity relationships, particularly in modelling the chromatographic retention times of polychlorinated biphenyls. Starting from molecular structure, viewed as a graph, and considering the bonds and bond types, atom types and often the 3D geometry of the molecule, a huge family of molecular...

The antituberculotic activity of some polyhydroxyxanthones was estimated using the Molecular Descriptors Family on Structure Activity Relationships methodology. From a total number of 298110 real and distinct calculated descriptors, 94843 were significantly different and entered into multiple linear regression analysis. The best performing bi-varied model was obtained by use of all polyhydroxyx...