The paper presents Ontology Definition Metamodel (ODM) that enables using Model Driven Architecture (MDA) standards in ontological engineering. Other similar metamodels are based on ontology representation languages, such as RDF(S), DAML+OIL, etc. However, none of these other solutions uses the recent W3C effort – The Web Ontology Language (OWL). In our approach, we firstly define the ODM place...

Dieser Beitrag beschreibt, wie Referenzarchitekturen die MDA nutzbar machen. Die Referenzarchitekturen liefern dabei die konzeptionelle Unterstützung für die Konstruktion und Implementierung von Software und die MDA bietet den Rahmen für eine Werkzeugunterstützung. Die praktische Umsetzbarkeit wird mit dem OpenSource Framework AndroMDA und einer Referenzarchitektur der Firma iteratec GmbH gezei...

p27 is a member of the Kip family of cyclin-dependent kinase inhibitors and its overexpression results in cell cycle arrest at G1 and/or apoptosis. In addition to its role as a regulator of cell cycle progression, p27 can also participate in cell motility, especially when it is mislocalized in the cytosol. To further elucidate the role of p27 in the motility of MDA-MB-231 breast cancer cells, w...

Induction of new bone formation is frequently seen in the bone lesions from prostate cancer. However, whether osteogenesis is necessary for prostate tumor growth in bone is unknown. Recently, 2 xenografts, MDA-PCa-118b and MDA-PCa-133, were generated from prostate cancer bone metastases. When implanted subcutaneously in severe combined immunodeficient (SCID) mice, MDA-PCa-118b induced strong ec...

OBJECTIVE To describe the minimal disease activity (MDA) rate over time in patients with psoriatic arthritis (PsA) receiving antitumour necrosis factor agents, evaluate prognostic factors of MDA achievement and identify the most common unmet criteria among MDA achievers. DESIGN Biologic Treatment Registry Across Canada (BioTRAC): ongoing, prospective registry of patients initiating treatment ...

PURPOSE The melanoma differentiation-associated gene-7 (MDA-7) protein, also known as interleukin (IL)-24, is a novel candidate of tumor suppressor that can induce apoptosis experimentally in a variety of human malignant cells including lung cancer cells. However, only one clinical study has documented that MDA-7/IL-24 expression is down-regulated with progression of melanoma. Thus, the present...

One of the open issues in Model Driven Architecture (MDA) is how to automatically transform the Platform Independent Model (PIM) over the Platform Specific Model (PSM) into source code currently this is only possible for a few domains using UML profiles, but the major goal is to minimize the required interaction by the programmer / designer at these steps in the general case. The idea is to def...

MDA wird als Zukunft des Software Engineering dargestellt. Trotz positiver Erfahrungsberichte vertreten wir die Auffassung, dass noch ein weiter Weg vor uns liegt, bis MDA in großem Maßstab eingesetzt wird. Dies ist bedingt durch die heute noch unbefriedigenden Möglichkeiten zur Dynamikmodellierung in UML. Wir präsentieren ein Architekturprinzip, das die von MDA postulierte Trennung von Anwendu...

Malondialdehyde (MDA) is a natural and widespread genotoxin. Given its potentially deleterious effects, it is of interest to establish the identities of the cell types containing this aldehyde. We used in situ chemical trapping with 2-thiobarbituric acid and mass spectrometry with a deuterated standard to characterize MDA pools in the vegetative phase in Arabidopsis thaliana. In leaves, MDA occ...