LTHOUGH mtich information about mast cells has become available in recent years ( reviews by Padawer,’ Uvn#{228}s,2Riley1 ) , little is known about the function of these cells. The relation of tissue mast cells to blood basophil leukocytes has been debated since their discovery. Because of their similar staining properties, Ehrlich4 regarded the latter as blood mast cells. The availability of a...

REFERENCES 1. Hegde S, Kaushal N, Ravindra KC, et al. delta12-pros-taglandin J3, an omega-3 fatty acid-derived metabolite, selectively ablates leukemia stem cells in mice. 2. Mozaffarian D, Lemaitre RN, King IB, et al. Circulating long-chain omega-3 fatty acids and incidence of congestive heart failure in older adults: the cardiovascular health study: a cohort study. polyunsaturated fatty acids...

Systemic Mastocytosis (SM) is a clonal disease characterized by abnormal accumulation of mast cells in multiple organs. Clinical presentations of the disease vary widely from indolent to aggressive forms, and to the exceedingly rare mast cell leukemia. Current treatment of aggressive SM and mast cell leukemia is unsatisfactory. An imatinib-resistant activating mutation of the receptor tyrosine ...

Systemic mastocytosis with associated clonal hematologic non-mast cell lineage disease (SMAHNMD) is a subtype of systemic mastocytosis (SM) characterized by neoplastic proliferation of mast cells in association with a hematologic neoplasm defined by the World Health Organization (WHO) criteria. SM-AHNMD is more commonly associated with myeloid neoplasms such as, chronic myelomonocytic leukemia ...

background : functional dyspepsia is considered one of the most common digestive diseases with tremendous cost and time expenditures for patients and health systems. an increase in the numbers of inflammatory cells such as mast cells and eosinophils are reported in the gastrointestinal mucosa of these patients. this study aims to determine the effects of histaminic receptor blockage on patients...

background: the aim of this study was to quantify the number of mast cells in focal reactive hyperplastic lesions of the oral cavity and to compare these two number of mast cells in normal gingival tissues and to correlate their presence with the state of connective tissue changes in reactive lesions and probably suggest a role for mast cells in these lesions. materials and methods: patient rec...

The stem cell leukemia (SCL) gene encodes a basic helix-loop-helix transcription factor expressed in erythroid, megakaryocyte, and mast-cell lineages. SCL is essential for growth of megakaryocyte and erythroid progenitors. We have used a conditional knockout of SCL (SCL(-/Delta)) to examine its function in mast cells, critical effectors of the immune system. SCL(-/Delta) mice had markedly incre...

background and aims. mast cells are one of the characteristic factors in angiogenesis, growth, and metastatic spread of tumors. the distribution and significance of mast cells in many tumors have been demonstrated. however, few studies have evaluated mast cell infiltration in salivary gland tumors. in this study, mast cell counts were evaluated in benign and malignant salivary gland tumors. mat...