In vitro culture systems using bone marrow cells from BALB/C mice were set up in medium supplemented with spleen-derived medium. Bone marrow cells grown in spleen-derived medium gave rise to cultures containing >97% mast cells. The cells were used in polarisation chemotaxis assays with the intention of determining the effect of nerve tissue-derived neurotransmitters on mast cell migration. ...

background: secretory proteins of ige receptor activated mast cells and basophils play a pivotal role in the generation of immediate and long term immune responses in allergy and type i hypersensitivity. objective: the present study aims to generate a 2-d map and profile of proteins secreted from a high secretory variant of the rat basophilic leukemia cell line, rbl-2h3.1, which in view of the ...

Abstract Background Numerous disorders can cause recurrent abdominal pain. Many of these cases underwent endoscopy and clinician encounters patients with history of recurrent abdominal pain and normal endoscopy. We evaluated these biopsies with regard to their eosinophils and mast cell densities to find out a potential relationship between recurrent abdominal pain with eosinophils and mast ce...

background & aim: according to presence of immune system factors in chronic periapical lesions, hypersensitivity reactions may have some role in pathogenesis of these lesions. up to now, among the factors participating in type i hypersensitivity reaction, only one of them has been studied. so the aim of this study was to evaluate the relationship between the presence of ige & number of mast cel...

ige-mediated cell signaling, induced by cross-linking of high affinity receptor for ige (fcεri) in the presence of antigen (ag), is a well known mechanism described for mast cell activation in allergy and hypersensitivity reactions, which induces a spectrum of cellular responses such as secretion and up-regulation of cell surface fcεri. although for several years  ige  binding  to  fcεri  was  ...

mast cells play an important role in a variety of inflammatory diseases, particularly asthma and atopy. peroxisome proliferator-activated receptor gamma (pparγ) is a member of the large nuclear hormone  receptor  transcription  factor  superfamily, and  has  been  recently implicated in the anti-inflammatory response. to investigate a possible role for pparγ in human mast cells, we studied the ...

abstract background numerous disorders can cause recurrent abdominal pain. many of these cases underwent endoscopy and clinician encounters patients with history of recurrent abdominal pain and normal endoscopy. we evaluated these biopsies with regard to their eosinophils and mast cell densities to find out a potential relationship between recurrent abdominal pain with eosinophils and mast cell...

Background: Secretory proteins of IgE receptor activated mast cells and basophils play a pivotal role in the generation of immediate and long term immune responses in allergy and type I hypersensitivity. Objective: The present study aims to generate a 2-D map and profile of proteins secreted from a high secretory variant of the rat basophilic leukemia cell line, RBL-2H3.1, which in view of the ...

Processed antigen reacts selectively with lymphocytes bearing .appropriate surface immunoglobulin molecules resulting in the clonal proliferation of these cells, produc­ing circulating immunoglobulin (humoral immunity) or non-circulating immunoglobulins (cellular immunity).  High levels of circulating immunoglobulins (lgM & lgG) occur in protozoa and helminths infections. Reaginic antibodies a...

Background and aim: Low-power lasers relief pain in some musculoskeletal disorders and accelerate wound healing process. However, there are few reports on effects of low-power lasers on mast cells. In this study the effects of low-power gallium aluminium arsenide laser (Ga.Al.As.laser) radiation on number and degranulation of mast cells of open skin wound bed of rats were studied using qu...