This is an addendum to the paper “Deformation of L∞-Algebras” [9]. We explain in which way the deformation theory of L∞-algebras extends the deformation theory of singularities. We show that the construction of semi-universal deformations of L∞-algebras gives explicit formal semiuniversal deformations of isolated singularities. Introduction In this paper, we apply the following general idea for...

Cerebral Dopamine Neurotrophic Factor (CDNF) and Mesencephalic Astrocyte-derived Neurotrophic factor (MANF) are members of a recently discovered family of neurotrophic factors (NTFs). Here, we used intranigral or intrastriatal lentiviral vector-mediated expression to evaluate their efficacy at protecting dopaminergic function in the 6-OHDA model of Parkinson's disease (PD). In contrast to the w...

The mesencephalic astrocyte-derived neurotrophic factor (MANF) belongs to a recently discovered family of neurotrophic factors. MANF can be secreted but is generally resident within the endoplasmic reticulum (ER) in neuronal and non-neuronal cells, where it is involved in the ER stress response with pro-survival effects. Here we report the discovery of the MANF homolog SDMANF in the sponge Sube...

A DNA genomic library constructed from Bacillus stearothermophilus, a gram-positive, facultative thermophilic aerobe that secretes a thermostable beta-mannanase, was screened for mannan hydrolytic activity. Recombinant beta-mannanase activity was detected on the basis of the clearing of halos around Escherichia coli colonies grown on a dye-labelled substrate, Remazol brilliant blue-locust bean ...

A DNA genomic library constructed from Bacillus stearothermophilus, a gram-positive, facultative thermophilic aerobe that secretes a thermostable b-mannanase, was screened for mannan hydrolytic activity. Recombinant b-mannanase activity was detected on the basis of the clearing of halos around Escherichia coli colonies grown on a dye-labelled substrate, Remazol brilliant blue-locust bean gum. T...

Although protein-misfolding-mediated neurodegenerative diseases have been linked to aging, how aging contributes to selective neurodegeneration remains unclear. We established spinocerebellar ataxia 17 (SCA17) knockin mice that inducibly express one copy of mutant TATA box binding protein (TBP) at different ages by tamoxifen-mediated Cre recombination. We find that more mutant TBP accumulates i...

Cerebral dopamine neurotrophic factor (CDNF) and mesencephalic astrocyte-derived (MANF) are involved in neuroprotection mitigating endoplasmic reticulum (ER) stress the brain peripheral organs. In earlier work, an increase histone acetylation, following treatment with epigenetic modulator, valproic acid, was associated induction of CDNF MANF cultured cells rat brain. These findings prompted inv...

Mesencephalic astrocyte-derived neurotrophic factor (MANF) is an endoplasmic reticulum (ER)–resident protein that plays a crucial role in attenuating ER stress responses. Although MANF indispensable for the survival and function of mouse ?-cells, its precise human ?-cell development unknown. In this study, we show lack humans results diabetes due to increased stress, leading impaired function. ...