This work examines the effects of six pesticides on five green algae: Pseudokirchneriella subcapitata, Scenedesmus quadricauda, Scenedesmus obliquus, Chlorella vulgaris and Chlorella pyrenoidosa. The results indicate that the decreasing order of the average toxicity to five algae was: fluazinam > propineb > maneb > mancozeb > zineb > bromoxynil octanoate. however, according to sensitivity magni...

Alpha synuclein (SNCA) genes and environmental factors are important risk factors of Parkinson's disease (PD). The agrichemicals paraquat, maneb and chlorpyrifos selectively target dopaminergic neurons, leading to parkinsonism, through ill-defined mechanisms. We analyzed the ability of low dose paraquat, maneb and chlorpyrifos, separately or combined together, to induce synucleinopathy in wild ...

Dithiocarbamates have emerged as potent carbonic anhydrase (CA) inhibitors in recent years. Given that CAs are important players in cellular metabolism, the objective of this work was to exploit the CA-inhibitory property of dithiocarbamates as a chemotherapeutic weapon against the Leishmania parasite. We report here strong antileishmanial activity of three hitherto unexplored metal dithiocarba...

In a population-based case-control study in California’s intensely agricultural Central Valley (2005–2006), the authors investigated relations between environmental pesticide/fungicide exposure and prostate cancer. Cases (n 1⁄4 173) were obtained from a population-based cancer registry, and controls (n 1⁄4 162) were obtained from Medicare listings and tax assessor mailings. Past ambient exposur...

In a population-based case-control study in California's intensely agricultural Central Valley (2005-2006), the authors investigated relations between environmental pesticide/fungicide exposure and prostate cancer. Cases (n = 173) were obtained from a population-based cancer registry, and controls (n = 162) were obtained from Medicare listings and tax assessor mailings. Past ambient exposures t...

Epidemiological studies indicate exposures to the herbicide paraquat (PQ) and fungicide maneb (MB) are associated with increased risk of Parkinson's disease (PD). Oxidative stress appears to be a premier mechanism that underlies damage to the nigrostriatal dopamine system in PD and pesticide exposure. Enhanced oxidative stress leads to lipid peroxidation and production of reactive aldehydes; th...

Dithiocarbamate fungicides such as maneb and mancozeb are widely used nonsystemic protectant fungicides to control various plant fungal diseases. Dithiocarbamate fungicides should be frequently applied to achieve optimal efficacy of disease control and avoid either decline in effectiveness or wash-off from leaf surface. Dithiocarbamates are of low resistance risk but have the potential to cause...

Ethylenebisdithiocarbamate (EBDC) fungicides are the most important class of organic fungicides and exhibit a high degree of carcinogenicity, mutagenicity, and neurotoxicity. For that reason, the safe application of these fungicides in practice requires a convenient method for their determination, applicable to biological fluids. We describe a high-performance liquid chromatography (HPLC) assay...

Parkinson's Disease (PD) is a degenerative neurological disorder that typically manifests symptoms in late adulthood, after loss of dopaminergic neurons in the nigrostriatal system. A lack of heritability for idiopathic PD has implicated adulthood environmental factors in the etiology of the disease. However, compelling evidence from animal models published within the past few years has shown t...

Technological advances and the search for efficiency have catalyzed recently a migration from paper-andpencil based way of doing things to computer-based in education and training at all levels with its drivers being faster administration, processing and delivery of examination results, error free marking of test items and enhanced interactivity. This research paper aims at establishing the cha...